152034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1836128..1836630 Replicon chromosome
Accession NZ_CP050031
Organism Escherichia coli strain 33-6

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G9P48_RS08740 Protein ID WP_000767829.1
Coordinates 1836376..1836630 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G9P48_RS08735 Protein ID WP_001259255.1
Coordinates 1836128..1836379 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P48_RS08710 1831306..1832373 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G9P48_RS08715 1832373..1833443 - 1071 WP_000108980.1 histidinol-phosphate transaminase -
G9P48_RS08720 1833440..1834744 - 1305 WP_001298841.1 histidinol dehydrogenase -
G9P48_RS08725 1834750..1835649 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
G9P48_RS08730 1835795..1835845 - 51 WP_001368802.1 his operon leader peptide -
G9P48_RS08735 1836128..1836379 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G9P48_RS08740 1836376..1836630 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G9P48_RS08745 1836713..1837537 + 825 WP_000754737.1 SDR family oxidoreductase -
G9P48_RS08750 1837583..1838512 + 930 WP_000803351.1 LysR family transcriptional regulator -
G9P48_RS08755 1838727..1838789 + 63 WP_010723108.1 membrane protein YoeI -
G9P48_RS08760 1838779..1840137 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G9P48_RS08765 1840316..1841374 + 1059 WP_000492315.1 transport protein YeeE -
G9P48_RS08770 1841388..1841615 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T152034 WP_000767829.1 NZ_CP050031:1836376-1836630 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T152034 NZ_CP065928:c1201420-1201154 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT152034 WP_001259255.1 NZ_CP050031:1836128-1836379 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT152034 NZ_CP065928:c1201683-1201420 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References