Detailed information of TA system TA152024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4150704..4151356
• Replicon: chromosome
• Accession: NZ_CP050013
• Organism: Serratia marcescens strain BP2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HAP49_RS19750
• Protein ID: WP_004931830.1
• Coordinates: 4150704..4151048 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: HAP49_RS19755
• Protein ID: WP_004931828.1
• Coordinates: 4151054..4151356 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP49_RS19740	4147045..4149303	-	2259	WP_004931835.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
HAP49_RS19745	4149525..4150544	+	1020	WP_004931832.1	HTH-type transcriptional regulator GalR	-
HAP49_RS19750	4150704..4151048	+	345	WP_004931830.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAP49_RS19755	4151054..4151356	+	303	WP_004931828.1	helix-turn-helix transcriptional regulator	Antitoxin
HAP49_RS19760	4151384..4152646	-	1263	WP_166445374.1	diaminopimelate decarboxylase	-
HAP49_RS19765	4152780..4153703	+	924	WP_076741314.1	LysR family transcriptional regulator	-
HAP49_RS19770	4153731..4154639	-	909	WP_015378928.1	LysR family transcriptional regulator	-
HAP49_RS19775	4154748..4155632	+	885	WP_015378929.1	MBL fold metallo-hydrolase	-
HAP49_RS19780	4155701..4156348	+	648	WP_015378930.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13383.44 Da
• Isoelectric Point: 10.6087

>T152024 WP_004931830.1 NZ_CP050013:4150704-4151048 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T152024 NZ_CP065925:169540-169806 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
AATTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT152024 WP_004931828.1 NZ_CP050013:4151054-4151356 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT152024 NZ_CP065925:169283-169540 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATGGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0