Detailed information of TA system TA152021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3410879..3411539
• Replicon: chromosome
• Accession: NZ_CP050013
• Organism: Serratia marcescens strain BP2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HAP49_RS16265
• Protein ID: WP_015378478.1
• Coordinates: 3411186..3411539 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A6G8TPX9
• Locus tag: HAP49_RS16260
• Protein ID: WP_004935502.1
• Coordinates: 3410879..3411181 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP49_RS16235	3406432..3407166	-	735	WP_166445251.1	SDR family oxidoreductase	-
HAP49_RS16240	3407203..3407838	-	636	WP_015378474.1	SDR family oxidoreductase	-
HAP49_RS16245	3407854..3408789	-	936	WP_075686398.1	alpha/beta hydrolase	-
HAP49_RS16250	3408789..3409709	-	921	WP_031300707.1	alpha/beta hydrolase	-
HAP49_RS16255	3409848..3410756	+	909	WP_088381767.1	LysR family transcriptional regulator	-
HAP49_RS16260	3410879..3411181	-	303	WP_004935502.1	XRE family transcriptional regulator	Antitoxin
HAP49_RS16265	3411186..3411539	-	354	WP_015378478.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAP49_RS16270	3411975..3413270	+	1296	WP_004935508.1	MFS transporter	-
HAP49_RS16275	3413297..3414103	+	807	WP_044030853.1	substrate-binding domain-containing protein	-
HAP49_RS16280	3414078..3414977	-	900	WP_015378480.1	LysR family transcriptional regulator	-
HAP49_RS16285	3415082..3415447	-	366	WP_004935528.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3404863..3432330	27467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13595.58 Da
• Isoelectric Point: 9.0493

>T152021 WP_015378478.1 NZ_CP050013:c3411539-3411186 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T152021 NZ_CP065924:243008-243274 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11142.96 Da
• Isoelectric Point: 5.1992

>AT152021 WP_004935502.1 NZ_CP050013:c3411181-3410879 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT152021 NZ_CP065924:242751-243008 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATGGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G8TPX9