Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3831621..3832297 Replicon chromosome
Accession NZ_CP049945
Organism Streptomyces koyangensis strain SCSIO 5802

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag G9U55_RS17160 Protein ID WP_203215193.1
Coordinates 3831621..3831983 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G9U55_RS17165 Protein ID WP_129848677.1
Coordinates 3831980..3832297 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9U55_RS17135 3826881..3827297 - 417 WP_003949884.1 ATP-binding protein -
G9U55_RS17140 3827297..3827677 - 381 WP_101279281.1 STAS domain-containing protein -
G9U55_RS17145 3827674..3828528 - 855 WP_129834261.1 STAS domain-containing protein -
G9U55_RS17150 3828821..3829063 + 243 WP_203215192.1 hypothetical protein -
G9U55_RS17155 3829155..3830729 - 1575 Protein_3371 hypothetical protein -
G9U55_RS17160 3831621..3831983 + 363 WP_203215193.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9U55_RS17165 3831980..3832297 + 318 WP_129848677.1 helix-turn-helix transcriptional regulator Antitoxin
G9U55_RS17170 3832377..3833159 - 783 WP_117349472.1 ABC transporter permease -
G9U55_RS17175 3833156..3834130 - 975 WP_203216619.1 ATP-binding cassette domain-containing protein -
G9U55_RS17180 3834246..3835121 - 876 WP_203215194.1 DUF4097 family beta strand repeat protein -
G9U55_RS17185 3835223..3835756 - 534 WP_129848675.1 toxin-antitoxin system HicB family antitoxin -
G9U55_RS17190 3835972..3837033 - 1062 WP_129848674.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13486.38 Da        Isoelectric Point: 4.7650

>T151815 WP_203215193.1 NZ_CP049945:3831621-3831983 [Streptomyces koyangensis]
MDGEWQIFLVDEVCVWIASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQWTEWYREAIPLAEHRYALYLKEREREEGGRP

Download         Length: 363 bp

>T151815 NZ_CP065748:2396740-2397006 [Delftia lacustris]
ATGGACATCGAATTCGACCCCGCCAAGAATCAGGCCAACATCGACAAGCACGGCGTTTCGCTGGAGATGGCGGGCCACAT
CGAATGGAGTGATGTTCTGTGCATGCCGGATGCGCGCCGGGACTACGGCGAAGTCCGCGAAATCGGCTTCGCTGTCATCG
GGCAACGGCTGTACGTTGTGGTGTTCGTGCAGCGCGGGCAGACCATGCGAATCGTCAGTCTCCGCAAGGCAAACTCCAGA
GAGGTCAAGGCTTATGAAGCAATCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11586.06 Da        Isoelectric Point: 9.8832

>AT151815 WP_129848677.1 NZ_CP049945:3831980-3832297 [Streptomyces koyangensis]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRRLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Download         Length: 318 bp

>AT151815 NZ_CP065748:2396993-2397286 [Delftia lacustris]
ATGAAGCAATCTAAGAAAGTGGGGCTGATCCAGCCCACGGCGGCCGAAGATGCCGCCATTGCCCGGGGCATCGAACAAGA
CCCGGACACCATGGAAATCACGGGCGACATGCTCGCCGGCATGCAAACGCTGGCCCGGCGTGGCCGGCCCCCACTGGAAC
AGCCAAAAATGCCCATGACCATGCGCGTGGACGCCGATGTGCTGGAGGCCATCAAGGCCACGGGGGCCGGATGGCAATCA
CGCGTCAATGAAGTGCTGCGGGAGGCCGTGAAAAAGGGCAAGCTGGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References