Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1801079..1801620 Replicon chromosome
Accession NZ_CP049936
Organism Escherichia coli strain JL05

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag G9V97_RS08670 Protein ID WP_000615976.1
Coordinates 1801342..1801620 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag G9V97_RS08665 Protein ID WP_000729704.1
Coordinates 1801079..1801339 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9V97_RS08640 1796862..1797647 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
G9V97_RS08645 1797619..1799331 + 1713 Protein_1691 flagellar biosynthesis protein FlhA -
G9V97_RS08650 1799436..1799714 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
G9V97_RS08655 1799707..1800063 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
G9V97_RS08660 1800120..1800893 - 774 WP_000543895.1 C40 family peptidase -
G9V97_RS08665 1801079..1801339 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
G9V97_RS08670 1801342..1801620 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
G9V97_RS08675 1801776..1802516 + 741 WP_001225679.1 murein L,D-transpeptidase -
G9V97_RS08680 1802487..1803254 - 768 WP_000333380.1 class II glutamine amidotransferase -
G9V97_RS08685 1803460..1804038 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 1799707..1817603 17896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T151792 WP_000615976.1 NZ_CP049936:1801342-1801620 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T151792 NZ_CP065728:c798495-798166 [Moraxella nonliquefaciens]
TTGACCTTTATTGAAACCAGTATTTTTACAAAAGCCATTAAAGAATTATTTGATGATGATGAATATCGCAAGATTCAAAA
TGAGCTGTTAAATGACCCACAAAAAGGGGATTTAATTCAAGGTACTGGTGGACTTAGAAAGATTCGTTTTGGTCGTAACA
GTGGCAAGAGTAGCGGAGTTAGAATCTTATATTATTATACAGATGAATTTGGTCGCATTTATCTGTTTGCGGTTTATCCA
AAATCCGTCAAAGATAATATTACTAATGCTGAAAAAGCGGTTTTTAAAACCCTTATCACCATACTAAAACAGGAGCTTAA
AAATGGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT151792 WP_000729704.1 NZ_CP049936:1801079-1801339 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT151792 NZ_CP065728:c798173-797892 [Moraxella nonliquefaciens]
ATGGATAAGCAACTATTTGATGACATCGTCGCTTCTATGAATGAAGCCATTGCCATTACAAAGGGCGAAATTGCCCCAAG
TCGTACATTCACCTATGAACGCCCAAACATCAAAGACATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGTTACATATTAGCCCTAAAACGCTTAGAAATTGGGAACAAGGCATTAGAACACCAACAGGCCCAGCCATTACCCTAATT
AGATTGCTTGACAAAAACCCTGATTTAATTAGCATGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References