Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2795343..2796043 Replicon chromosome
Accession NZ_CP049918
Organism Bordetella bronchiseptica strain KVNON-570

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3LPJ8
Locus tag G6545_RS12955 Protein ID WP_003809515.1
Coordinates 2795747..2796043 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag G6545_RS12950 Protein ID WP_003809516.1
Coordinates 2795343..2795744 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6545_RS12920 2790528..2791550 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
G6545_RS12925 2791687..2792724 - 1038 WP_003809529.1 threonylcarbamoyl-AMP synthase -
G6545_RS12930 2792744..2793934 - 1191 WP_003809527.1 5-(carboxyamino)imidazole ribonucleotide synthase -
G6545_RS12935 2793937..2794452 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
G6545_RS12940 2794600..2795079 - 480 WP_003809523.1 disulfide bond formation protein B -
G6545_RS12945 2795087..2795323 - 237 WP_003809519.1 hypothetical protein -
G6545_RS12950 2795343..2795744 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
G6545_RS12955 2795747..2796043 - 297 WP_003809515.1 type II toxin-antitoxin system MqsR family toxin Toxin
G6545_RS12960 2796326..2797207 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
G6545_RS12965 2797433..2797879 + 447 WP_003809511.1 GFA family protein -
G6545_RS12970 2797965..2799029 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
G6545_RS12975 2799205..2799747 - 543 WP_165645890.1 MOSC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10608.50 Da        Isoelectric Point: 7.9291

>T151767 WP_003809515.1 NZ_CP049918:c2796043-2795747 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

>T151767 NZ_CP065706:603222-603587 [Streptococcus oralis]
GTGCACACGATTTACTTCTATAAGGACAAAAATGGAAACGAGCCAGTCTTAGATTATATGAGAGAATTGGCTAGAAAGAA
GAGTAAGGATAGTCGCATCAAACTCAATAAACTAAACGACTATATCGAGTTGCTTAGTCAGCATGGGACTAGAACTGGTG
AACCCTATATCAAACATTTGGAAGATGAGATTTGGGAACTAAGACCTCTGAGGGATAGAATTTTATTTGTAGCGTGGCTT
GATGGGAGTTTTGTTCTCTTACATCATTTTGTCAAAAAGACTCAGAAAACTCCTAGGAGAGAAATTGAAAAAGCCAAGCG
TGAACTGAAAGACATAAAAGAAAGAGGGGTAAGTGATGAAGAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT151767 WP_003809516.1 NZ_CP049918:c2795744-2795343 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT151767 NZ_CP065706:603577-603870 [Streptococcus oralis]
ATGAAGAATAGTGCTATTGGAAGTAATTGGAAAGATGTCCGCTCTGAGCTCTTCACTAAGGAGGAAATCCTTGAAAGTGA
TATGCGAGTAGCTATTATGAGTGAATTGATTGAAGCTAGACGTGAGAAAGGAATTAGTCAGAAAAAGCTAGAAGAACTTA
GTGGAGTGAGTCAGCCTGTCATAGCTAGGATGGAAACAGGCAAGACTAGCCCTCAATTGGATACGGTCTTAAAAGTTTTA
GCCAGTTTGGGAAAGACACTAGCAGTCGTTCCACTTGAACAGGAAAAAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3LPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References