Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 565517..566132 | Replicon | plasmid p_unnamed1 |
| Accession | NZ_CP049914 | ||
| Organism | Vibrio sp. HDW18 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | G7083_RS14340 | Protein ID | WP_001162670.1 |
| Coordinates | 565845..566132 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | G7083_RS14335 | Protein ID | WP_166015479.1 |
| Coordinates | 565517..565834 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G7083_RS14300 | 561091..561827 | - | 737 | Protein_491 | transposase | - |
| G7083_RS14305 | 561917..562216 | - | 300 | WP_166013939.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G7083_RS14310 | 562258..562566 | - | 309 | WP_166013938.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G7083_RS14315 | 562711..563031 | + | 321 | WP_166013944.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G7083_RS14320 | 563028..563381 | + | 354 | WP_166013945.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G7083_RS14325 | 563441..564970 | + | 1530 | WP_166013947.1 | IS66 family transposase | - |
| G7083_RS15030 | 565410..565520 | - | 111 | WP_082798255.1 | DUF3265 domain-containing protein | - |
| G7083_RS14335 | 565517..565834 | - | 318 | WP_166015479.1 | HigA family addiction module antidote protein | Antitoxin |
| G7083_RS14340 | 565845..566132 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G7083_RS14345 | 566243..566365 | - | 123 | Protein_500 | DUF3265 domain-containing protein | - |
| G7083_RS14350 | 566362..567246 | - | 885 | WP_095466730.1 | hypothetical protein | - |
| G7083_RS14355 | 567389..568006 | - | 618 | WP_041051877.1 | hypothetical protein | - |
| G7083_RS14360 | 568145..568348 | - | 204 | WP_001933740.1 | hypothetical protein | - |
| G7083_RS14365 | 568495..568620 | - | 126 | WP_166015480.1 | DUF3265 domain-containing protein | - |
| G7083_RS14370 | 568602..569453 | - | 852 | WP_001893680.1 | putative phage abortive infection protein | - |
| G7083_RS14375 | 569648..569929 | - | 282 | WP_001100053.1 | hypothetical protein | - |
| G7083_RS14380 | 570285..570743 | + | 459 | WP_166015481.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | hlyA | 1..599487 | 599487 | |
| - | inside | IScluster/Tn | - | - | 555277..564970 | 9693 | |
| - | inside | Integron | catB9 | hlyA | 3..599486 | 599483 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T151761 WP_001162670.1 NZ_CP049914:c566132-565845 [Vibrio sp. HDW18]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T151761 NZ_CP065700:2095928-2096233 [Atlantibacter hermannii]
ATGAGAAAAGGAACACCCAACGTCCCTCTGAGCGTGGTGAAAGAAATGGTGCGGTCAGGCAAAGTCAAAACCACCTTTAC
CGCCACGCAAGGCGCGCTTGAATTAGGCTTCCCCGCGCCAGTGTTACCCTTAATGTGCAAAGTTGTTTTGCTGCTGGACC
AGAGTCATTTTTATAAAAGTATGACTGCGTATCATGATGAAACCATCTGGCATGATGTGTATCGCACGCGTTTCGACGAA
CGCCATATCTATCTTAAGCTTATCGTGAAAGATGACGTCCTGATTGTGTCATTTAAGGAGTTATGA
ATGAGAAAAGGAACACCCAACGTCCCTCTGAGCGTGGTGAAAGAAATGGTGCGGTCAGGCAAAGTCAAAACCACCTTTAC
CGCCACGCAAGGCGCGCTTGAATTAGGCTTCCCCGCGCCAGTGTTACCCTTAATGTGCAAAGTTGTTTTGCTGCTGGACC
AGAGTCATTTTTATAAAAGTATGACTGCGTATCATGATGAAACCATCTGGCATGATGTGTATCGCACGCGTTTCGACGAA
CGCCATATCTATCTTAAGCTTATCGTGAAAGATGACGTCCTGATTGTGTCATTTAAGGAGTTATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11671.61 Da Isoelectric Point: 10.4711
>AT151761 WP_166015479.1 NZ_CP049914:c565834-565517 [Vibrio sp. HDW18]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKLVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKLVKPLFVSLEQSART
Download Length: 318 bp
>AT151761 NZ_CP065700:2096233-2096637 [Atlantibacter hermannii]
ATGAAAACTTGTCCCGTTTGTGGCGGCGGCCATTTAACTCATGAAAGCCGCGATCTGCCCTATGAATACAAAGGCAGCAA
AACAACCTTGCGTGGGATTGTTGGCGAATATTGCAATTCCTGCGGTGAAATTATCTTTACTCCTGAAGAAAGCAACGCCT
TTAGCGCTCAGGCCTCAGCCTTCCGCACTGCGGTGAATGCAGAATCTTTCGACCCGACGCTGTTTACCCGGGTGCGTAAA
AATTTGCGCATCGATCAGCAACAGGCCGGTATGCTGTTTGGCGGCGGCGTAAATGCCTTTTCGCGTTATGAAACAGGGAA
AACCACGCCGCCGATAGCCGTGGTGAAACTCTTTAAAATGTTTGATAAGTTCCCGGAATTATTCGAAGAATACAAATCGC
TGTAA
ATGAAAACTTGTCCCGTTTGTGGCGGCGGCCATTTAACTCATGAAAGCCGCGATCTGCCCTATGAATACAAAGGCAGCAA
AACAACCTTGCGTGGGATTGTTGGCGAATATTGCAATTCCTGCGGTGAAATTATCTTTACTCCTGAAGAAAGCAACGCCT
TTAGCGCTCAGGCCTCAGCCTTCCGCACTGCGGTGAATGCAGAATCTTTCGACCCGACGCTGTTTACCCGGGTGCGTAAA
AATTTGCGCATCGATCAGCAACAGGCCGGTATGCTGTTTGGCGGCGGCGTAAATGCCTTTTCGCGTTATGAAACAGGGAA
AACCACGCCGCCGATAGCCGTGGTGAAACTCTTTAAAATGTTTGATAAGTTCCCGGAATTATTCGAAGAATACAAATCGC
TGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|