Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 558281..558758 Replicon plasmid p_unnamed1
Accession NZ_CP049914
Organism Vibrio sp. HDW18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7083_RS14280 Protein ID WP_166015477.1
Coordinates 558609..558758 (-) Length 50 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7083_RS14275 Protein ID WP_001232701.1
Coordinates 558281..558598 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7083_RS14245 555277..556427 + 1151 WP_166015475.1 IS3 family transposase -
G7083_RS14250 556442..556699 - 258 WP_206212130.1 hypothetical protein -
G7083_RS15025 556688..556818 - 131 Protein_482 acetyltransferase -
G7083_RS14260 556921..557322 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
G7083_RS14265 557322..557492 - 171 WP_166015532.1 acetyltransferase -
G7083_RS14270 557683..558096 - 414 WP_166015476.1 VOC family protein -
G7083_RS14275 558281..558598 - 318 WP_001232701.1 HigA family addiction module antidote protein Antitoxin
G7083_RS14280 558609..558758 - 150 WP_166015477.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7083_RS14285 558812..559120 + 309 WP_166013938.1 IS66 family insertion sequence element accessory protein TnpB -
G7083_RS14290 559162..559461 + 300 WP_166013939.1 IS66 family insertion sequence element accessory protein TnpB -
G7083_RS14295 559551..561055 + 1505 Protein_490 IS66 family transposase -
G7083_RS14300 561091..561827 - 737 Protein_491 transposase -
G7083_RS14305 561917..562216 - 300 WP_166013939.1 IS66 family insertion sequence element accessory protein TnpB -
G7083_RS14310 562258..562566 - 309 WP_166013938.1 IS66 family insertion sequence element accessory protein TnpB -
G7083_RS14315 562711..563031 + 321 WP_166013944.1 IS66 family insertion sequence element accessory protein TnpB -
G7083_RS14320 563028..563381 + 354 WP_166013945.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyA 1..599487 599487
- inside IScluster/Tn - - 555277..564970 9693
- inside Integron catB9 hlyA 3..599486 599483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-47)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5917.84 Da        Isoelectric Point: 10.1030

>T151760 WP_166015477.1 NZ_CP049914:c558758-558609 [Vibrio sp. HDW18]
VGLNRRLRFEHLEGNLKGWCSIRVNKQYRLIFQWVDGVALNTYLDPHKY

Download         Length: 150 bp

>T151760 NZ_CP065700:683299-683718 [Atlantibacter hermannii]
GTGGTCCTGTGGCAATCTGATCTACGCGTCTCATGGCGCGCACAATGGTTTTCGCTCATGCTTCACGGCATTGTTGCGGC
TATTATTTTATTGCTGCCCTGGCCGTTGAGTTACATGCCGCTCTGGCTGATTTTATTATCATTAGTGGTATTTGATTGCG
TGCGCAGCCAACGGCGCATCCATTCACTGCAAGGTGAAGTCAAACTGACAATTGATTATCGGTTGCGCTGGCAAGGTATC
GAGTGGGAACTGACGGCTGCGCCCTGGATGCTGCAAAGCGGCATGTTGCTGCGCTTGCGTCACCCGGATACACATCGCAG
CCAGCATTTATGGCTTGCGGCAGACAGTATGGACGCAGGCGAATGGCGTGATTTACGGCGGATATTAATGCAGCAACCGC
AAAGCGGTCGCCATCCCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT151760 WP_001232701.1 NZ_CP049914:c558598-558281 [Vibrio sp. HDW18]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT151760 NZ_CP065700:683052-683318 [Atlantibacter hermannii]
ATGGATATTAATAATAAAGCCCGTATCCACTGGGCATGCCGTCGCGGGATGCGTGAGCTGGATATCTCTATCATGCCGTT
CTTTGAACACGAGTATGACACCCTGAGCGACGACGACAAACGCGTGTTTATTCGTTTGCTCGAATGCGACGACCCCGATC
TTTTTAACTGGTTAATGAATCACGGTAAGCCTGCGGACAGTGAATTGCAGCGCATGGTGCAAATGATTCAAACACGGAAC
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References