Detailed information of TA system TA151754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4804721..4805421
• Replicon: chromosome
• Accession: NZ_CP049910
• Organism: Diaphorobacter sp. HDW4A

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: G7047_RS22080
• Protein ID: WP_166310063.1
• Coordinates: 4804721..4805017 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: G7047_RS22085
• Protein ID: WP_166310065.1
• Coordinates: 4805020..4805421 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7047_RS22070	4800992..4803958	-	2967	WP_166310059.1	Tn3 family transposase	-
G7047_RS22075	4803961..4804518	-	558	WP_166310061.1	recombinase family protein	-
G7047_RS22080	4804721..4805017	+	297	WP_166310063.1	type II toxin-antitoxin system MqsR family toxin	Toxin
G7047_RS22085	4805020..4805421	+	402	WP_166310065.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
G7047_RS22090	4805755..4807500	-	1746	WP_079862784.1	alpha/beta-hydrolase family protein	-
G7047_RS22095	4807913..4808638	+	726	WP_166310067.1	aspartate/glutamate racemase family protein	-
G7047_RS22100	4808638..4809135	+	498	WP_166310069.1	DUF3592 domain-containing protein	-
G7047_RS22105	4810115..4810396	+	282	WP_166310071.1	DUF427 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4798169..4826732	28563

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10609.36 Da
• Isoelectric Point: 7.2756

>T151754 WP_166310063.1 NZ_CP049910:4804721-4805017 [Diaphorobacter sp. HDW4A]
MEKGTPHCKLPVVKAMIEAGKVRSTLSALAGGAALGFDFEGIVSVVKALTPADFYKSMTTHADHRVWQDVYRPATSAGEV
YLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T151754 NZ_CP065699:2701768-2701971 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14339.51 Da
• Isoelectric Point: 6.9050

>AT151754 WP_166310065.1 NZ_CP049910:4805020-4805421 [Diaphorobacter sp. HDW4A]
MKCPSCAAAELVRDTRDLPYTYKGETTLIPAVTGDFCPACGEAVLDVAESTRTSAAMLEFNKQVNASIVDPGFIASVRKK
LALDQREAAEIFGGGVNAFSRYENGKTKPPLALVKLLKVLDRHPDLLNEVRAA

Nucleotide

• Length: 402 bp

>AT151754 NZ_CP065699:2701349-2701717 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG