Detailed information of TA system TA151744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2259087..2259690
• Replicon: chromosome
• Accession: NZ_CP049885
• Organism: Acidovorax sp. HDW3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: G7045_RS10365
• Protein ID: WP_166159564.1
• Coordinates: 2259409..2259690 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: G7045_RS10360
• Protein ID: WP_166159563.1
• Coordinates: 2259087..2259386 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7045_RS10300	2254136..2254474	-	339	WP_166159552.1	hypothetical protein	-
G7045_RS10305	2254471..2254623	-	153	WP_166159553.1	hypothetical protein	-
G7045_RS10310	2254635..2254772	-	138	WP_166159554.1	hypothetical protein	-
G7045_RS10315	2254763..2255050	-	288	WP_166159555.1	hypothetical protein	-
G7045_RS10320	2255047..2255637	-	591	WP_166159556.1	hypothetical protein	-
G7045_RS10325	2255757..2256170	-	414	WP_166160431.1	ogr/Delta-like zinc finger family protein	-
G7045_RS10330	2256234..2256506	-	273	WP_166159557.1	hypothetical protein	-
G7045_RS10335	2256503..2256706	-	204	WP_166159558.1	hypothetical protein	-
G7045_RS10340	2256727..2256936	-	210	WP_166159559.1	hypothetical protein	-
G7045_RS10345	2257048..2257719	+	672	WP_166159560.1	helix-turn-helix domain-containing protein	-
G7045_RS10350	2257798..2258340	+	543	WP_166159561.1	zinc chelation protein SecC	-
G7045_RS10355	2258451..2259008	-	558	WP_166159562.1	hypothetical protein	-
G7045_RS10360	2259087..2259386	-	300	WP_166159563.1	HigA family addiction module antidote protein	Antitoxin
G7045_RS10365	2259409..2259690	-	282	WP_166159564.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G7045_RS10370	2259732..2260835	-	1104	WP_166159565.1	phage late control D family protein	-
G7045_RS10375	2260835..2261287	-	453	WP_166159566.1	phage tail protein	-
G7045_RS10380	2261309..2263936	-	2628	WP_166159567.1	phage tail protein	-
G7045_RS10385	2263964..2264212	-	249	WP_166159568.1	hypothetical protein	-
G7045_RS10390	2264285..2264413	-	129	WP_166159569.1	GpE family phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2246525..2284582	38057

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (25-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10815.52 Da
• Isoelectric Point: 10.2185

>T151744 WP_166159564.1 NZ_CP049885:c2259690-2259409 [Acidovorax sp. HDW3]
MAIQSFKCHDTQTLFTLQRVRRWISIEAVALRKLRMLHAAADLRDLLIPPGNRLEALRGDRAGQHSIRINDQWRVCFVWT
AQGPSHVEIVDYH

Nucleotide

• Length: 282 bp

>T151744 NZ_CP065695:1495558-1495854 [Delftia acidovorans]
ATGAGCAACATCAAGATGCGGCCATTCGACATGGCCAACTACCTCGGCACCGAAGAGGAAATCGTGGAGTACCTGCGCCA
GGCGCTGGAAGACAACGATCCGGCCGAACTGGCTGCGGCGCTGGGCGACATCGCACGCGCGCGCGGCATGACTCAGCTCG
CTCGCGACACCGGACTTTCTCGGGAAAGCCTCTACAAAAGCCTGTCTGGCGAACGGGCGCCCAGTTCCGAGACGCTGTTC
AAGGTGATTCAGGCCATGGGCTTCAGGCTCACCATCGCTCCTGCCGCATCGCAGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10898.61 Da
• Isoelectric Point: 8.5630

>AT151744 WP_166159563.1 NZ_CP049885:c2259386-2259087 [Acidovorax sp. HDW3]
MTHRLTLPTPGEVLAAEFLQPLGITPYRLAKEIHVPQTRIAAIIKGGRTITADTALRLARYFGTSAAFWLNLQQQYDTDT
AAQRLAQELANIEPLALLA

Nucleotide

• Length: 300 bp

>AT151744 NZ_CP065695:1495265-1495561 [Delftia acidovorans]
ATGTACAGCGTCATCGAAACCGAGGCGTTTGCTGATTGGGTAGACAGCATTCGTGACATACCAACTCGTATCCGCCTGCG
TCGTCGCCTGGGCAAAGCCATGCGCGGAAACCTGGGAGACGTGAAATCCGTTGGCGAGGGCCTATGGGAGATGCGCGAGT
TTTTTGGGCCAGGTTGGCGCATGTACTACATCCAACGCGATCATGTTCTGATCGTGATGCTTGGCGGCGGAGACAAGTCC
AGCCAGGCACAGGACATTGCTGCGGCCAGGGCGATGGCCAGGGAGATCAAGCTATGA