Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3025739..3026309 Replicon chromosome
Accession NZ_CP049863
Organism Leucobacter viscericola strain HDW9C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7068_RS13095 Protein ID WP_166292369.1
Coordinates 3026028..3026309 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7068_RS13090 Protein ID WP_166292368.1
Coordinates 3025739..3026041 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7068_RS13055 3020885..3021370 - 486 WP_166292363.1 DUF4307 domain-containing protein -
G7068_RS13060 3021457..3022326 + 870 WP_205881298.1 mycothiol conjugate amidase Mca -
G7068_RS13065 3022323..3022562 + 240 WP_166292364.1 hypothetical protein -
G7068_RS13070 3022569..3024590 + 2022 WP_205881299.1 DNA helicase RecQ -
G7068_RS13075 3024597..3025061 - 465 WP_166292365.1 SRPBCC domain-containing protein -
G7068_RS13080 3025096..3025482 - 387 WP_166292366.1 type II toxin-antitoxin system PemK/MazF family toxin -
G7068_RS13085 3025430..3025660 - 231 WP_166292367.1 ribbon-helix-helix domain-containing protein -
G7068_RS13090 3025739..3026041 - 303 WP_166292368.1 HigA family addiction module antidote protein Antitoxin
G7068_RS13095 3026028..3026309 - 282 WP_166292369.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7068_RS13100 3026405..3027169 - 765 WP_166292370.1 hemolysin III family protein -
G7068_RS13105 3027285..3028070 + 786 WP_166292371.1 isoprenyl transferase -
G7068_RS13110 3028072..3028887 + 816 WP_166292372.1 SDR family oxidoreductase -
G7068_RS13115 3028911..3030248 + 1338 WP_166292373.1 amidohydrolase -
G7068_RS13120 3030251..3030658 + 408 WP_205881300.1 DUF1801 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11026.42 Da        Isoelectric Point: 8.0426

>T151741 WP_166292369.1 NZ_CP049863:c3026309-3026028 [Leucobacter viscericola]
VIRSFGSKDTERLWRRERVPSIDPRIHQVALRKLRQVGSAESLDDLRIPPGNRLEQLRGDRAGQYSVRINNQWRICFVWT
DTEPEEVEIVDYH

Download         Length: 282 bp

>T151741 NZ_CP065693:2777804-2777907 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.68 Da        Isoelectric Point: 5.0041

>AT151741 WP_166292368.1 NZ_CP049863:c3026041-3025739 [Leucobacter viscericola]
MTTTNKLEPVHPGEVLLVDFIDGFSITQNKLAVSIDVPPRRINEIVHGKRGISADTALRLARFFGTSAQFWLNLQTQFDL
DLADDRIAEQLAAITPLQVA

Download         Length: 303 bp

>AT151741 NZ_CP065693:c2777911-2777769 [Enterobacter asburiae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References