Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 1004204..1004898 | Replicon | chromosome |
| Accession | NZ_CP049852 | ||
| Organism | Escherichia coli strain UPEC-774U/190308 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1PJQ2 |
| Locus tag | G9W34_RS04815 | Protein ID | WP_001263500.1 |
| Coordinates | 1004500..1004898 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1QAE3 |
| Locus tag | G9W34_RS04810 | Protein ID | WP_000554758.1 |
| Coordinates | 1004204..1004497 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G9W34_RS04785 (1000021) | 1000021..1000488 | + | 468 | WP_000725261.1 | flagellar basal body-associated FliL family protein | - |
| G9W34_RS04790 (1000508) | 1000508..1001224 | + | 717 | WP_000938731.1 | FliA/WhiG family RNA polymerase sigma factor | - |
| G9W34_RS04795 (1001237) | 1001237..1002100 | + | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
| G9W34_RS04800 (1002103) | 1002103..1003026 | + | 924 | WP_001532973.1 | putative lateral flagellar export/assembly protein LafU | - |
| G9W34_RS04805 (1003097) | 1003097..1004152 | + | 1056 | WP_001226168.1 | DNA polymerase IV | - |
| G9W34_RS04810 (1004204) | 1004204..1004497 | + | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| G9W34_RS04815 (1004500) | 1004500..1004898 | + | 399 | WP_001263500.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| G9W34_RS04820 (1004908) | 1004908..1005360 | + | 453 | WP_001059895.1 | GNAT family N-acetyltransferase | - |
| G9W34_RS04825 (1005550) | 1005550..1006689 | + | 1140 | WP_000521561.1 | RNA ligase RtcB family protein | - |
| G9W34_RS04830 (1006686) | 1006686..1007300 | + | 615 | WP_000602124.1 | peptide chain release factor H | - |
| G9W34_RS04835 (1007357) | 1007357..1008814 | - | 1458 | WP_001292999.1 | cytosol nonspecific dipeptidase | - |
| G9W34_RS04840 (1009075) | 1009075..1009533 | + | 459 | WP_001291991.1 | xanthine phosphoribosyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15413.85 Da Isoelectric Point: 8.9511
>T151716 WP_001263500.1 NZ_CP049852:1004500-1004898 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T151716 NZ_CP065685:c195456-194977 [Burkholderia humptydooensis]
ATGACGGTTGCGCTCTGGCGAATCGCAACCGACACGCCCGACTACACGGCGGACGACCTAAGCGGCGAAGGGGCGAAACG
CACCGGTGGTCGCTGGAACCGGTCGGGTCGCGCCGTGCTGTACACGGCCTCGAACATCGCGCTCGCCTGCCTCGAGACAG
TTGTTCATCTGAGCGGCGGAGACTTGCCACTCAACCGTTATCTGGTCCGCCTCGAGGTCCCCGACGAGGTGTGGGCGAAG
GCTCGCACCCTCGATGCGACATCGGCACCAGTGGGCTGGGACGCTTTGCCGGCCGGCAAGGTCAGTCTGGATCTCGGTGA
CGCGTGGCTGTCAGAGGGCGCTACCGCGCTGTACTGCGTGCCGTCGGTCGTCGTCCCGGAGGAGGTGAACGTGCTGATCA
ATCCCGCGCACCTGGATACGCGACACATCACTGCTACCAAGCTGCGCCGTTGGACCTATGACGCGCGCGTCTGGGCATAG
ATGACGGTTGCGCTCTGGCGAATCGCAACCGACACGCCCGACTACACGGCGGACGACCTAAGCGGCGAAGGGGCGAAACG
CACCGGTGGTCGCTGGAACCGGTCGGGTCGCGCCGTGCTGTACACGGCCTCGAACATCGCGCTCGCCTGCCTCGAGACAG
TTGTTCATCTGAGCGGCGGAGACTTGCCACTCAACCGTTATCTGGTCCGCCTCGAGGTCCCCGACGAGGTGTGGGCGAAG
GCTCGCACCCTCGATGCGACATCGGCACCAGTGGGCTGGGACGCTTTGCCGGCCGGCAAGGTCAGTCTGGATCTCGGTGA
CGCGTGGCTGTCAGAGGGCGCTACCGCGCTGTACTGCGTGCCGTCGGTCGTCGTCCCGGAGGAGGTGAACGTGCTGATCA
ATCCCGCGCACCTGGATACGCGACACATCACTGCTACCAAGCTGCGCCGTTGGACCTATGACGCGCGCGTCTGGGCATAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT151716 WP_000554758.1 NZ_CP049852:1004204-1004497 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT151716 NZ_CP065685:c195956-195453 [Burkholderia humptydooensis]
ATGAGCGCGATCGAGAAACGACATGCCCTGCCTGCACGCGCGCGGCCGCGTGCGGTCGAGCCGCACGAGCTCGAATTGCT
CGACTTTCAGCGGATTTACCGCGCCTCGCCGATGGAACGTATTGACTGGATCAAGCATGGGGTCGACGCCCACACCGTGA
TTCTGCTCGCCGATCGCATGGCGACCACGCAGGACCGGCTCATGGGCGTCCTCGGATTTCCGCGAACGACGGTGGTCCGC
AAGTCGAAGGCAAAACAGCCGCTGTCAACCGAGCACACAGAGCGCGTTGTGGGCCTGTCGAAGCTGATCGGTCAGGTTCA
GTCTATGGTTGAGGAATCCGGCGAACCGGCCGGGTTCGACGCCGCTCATTGGGTCGCGCAGTGGATCGAGCGGACCAATC
CCGCTTTGGGTGGCCGCAAGCCGGCGGAATTGATGGATACCGTTGCAGGCCAGGAGCTCGTCGGCGCCGTGCTCGCACGG
ATGCAAAGCGGAGCATATGCATGA
ATGAGCGCGATCGAGAAACGACATGCCCTGCCTGCACGCGCGCGGCCGCGTGCGGTCGAGCCGCACGAGCTCGAATTGCT
CGACTTTCAGCGGATTTACCGCGCCTCGCCGATGGAACGTATTGACTGGATCAAGCATGGGGTCGACGCCCACACCGTGA
TTCTGCTCGCCGATCGCATGGCGACCACGCAGGACCGGCTCATGGGCGTCCTCGGATTTCCGCGAACGACGGTGGTCCGC
AAGTCGAAGGCAAAACAGCCGCTGTCAACCGAGCACACAGAGCGCGTTGTGGGCCTGTCGAAGCTGATCGGTCAGGTTCA
GTCTATGGTTGAGGAATCCGGCGAACCGGCCGGGTTCGACGCCGCTCATTGGGTCGCGCAGTGGATCGAGCGGACCAATC
CCGCTTTGGGTGGCCGCAAGCCGGCGGAATTGATGGATACCGTTGCAGGCCAGGAGCTCGTCGGCGCCGTGCTCGCACGG
ATGCAAAGCGGAGCATATGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|