Detailed information of TA system TA151701

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 25506..25775
• Replicon: plasmid pEcoUTI1d
• Accession: NZ_CP049848
• Organism: Escherichia coli strain UPEC-245U/190328

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: G9W35_RS25755
• Protein ID: WP_001372321.1
• Coordinates: 25650..25775 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	25506..25571 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W35_RS25715	20530..20766	+	237	WP_162756886.1	hypothetical protein	-
G9W35_RS25720	21275..21814	+	540	WP_000290847.1	single-stranded DNA-binding protein	-
G9W35_RS25725	21876..22109	+	234	WP_001519997.1	DUF905 family protein	-
G9W35_RS25730	22174..24132	+	1959	WP_221522810.1	ParB/RepB/Spo0J family partition protein	-
G9W35_RS25735	24187..24621	+	435	WP_000845910.1	conjugation system SOS inhibitor PsiB	-
G9W35_RS25740	24618..25380	+	763	Protein_34	plasmid SOS inhibition protein A	-
G9W35_RS25745	25349..25537	-	189	WP_001336239.1	hypothetical protein	-
-	25349..25573	+	225	NuclAT_0	-	-
-	25349..25573	+	225	NuclAT_0	-	-
-	25349..25573	+	225	NuclAT_0	-	-
-	25349..25573	+	225	NuclAT_0	-	-
-	25506..25571	+	66	-	-	Antitoxin
G9W35_RS25750	25559..25708	+	150	Protein_36	plasmid maintenance protein Mok	-
G9W35_RS25755	25650..25775	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
G9W35_RS25760	26094..26391	-	298	Protein_38	hypothetical protein	-
G9W35_RS25765	26691..26987	+	297	WP_001272251.1	hypothetical protein	-
G9W35_RS25770	27098..27919	+	822	WP_001234445.1	DUF932 domain-containing protein	-
G9W35_RS25775	28216..28725	-	510	WP_000759173.1	transglycosylase SLT domain-containing protein	-
G9W35_RS25780	29139..29522	+	384	WP_001151538.1	conjugal transfer relaxosome DNA-binding protein TraM	-
G9W35_RS25785	29709..30398	+	690	WP_016239105.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..68488	68488

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T151701 WP_001372321.1 NZ_CP049848:25650-25775 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T151701 NZ_CP065673:c2088918-2087620 [Serratia plymuthica]
GTGGACAAGCTACGTGTGGCGCTGAATGGTACTGTTGTAGGGACGCTGGAAAAGCATGCGGGCGGCGCGATGTCGTTTGT
TTACCACGAGGAGTGGCTGGCACAAGCCGGTGCGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCGTTTCGCG
GTGACGTGGTGTATAACTTTTTCGACAACCTGTTGCCGGACAGCGAGTTTATTCGCAGCCGCCTACAGGCGCGTTTTAGA
ACGGCAACCAAACAGCCTTTTGATCTGCTTTCCAGCATTGGCAGCGACTGCGTGGGGGCGATCCAGCTTTACCCTGAACA
TGCCGATATGGCCCCGGTAAAGCAAGTGAACGCCGTGCCTGTGAGTGACGAAGAAATAGAGCAACTTCTGCTGGGGTACC
GCGAGGCGCCGTTGGGCATGGTGGCGGGTACGGATGATTTCCGGATCTCTCTGGCGGGTGCGCAGGAAAAGACCGCGCTG
CTTTGGTTCGGCAATCAGTGGTATCGGCCACAGGGGAGTACGCCAACCAGCCACATTATAAAACTGCCCATTGGGCATAT
CGCGCATAACAATCTGGATCTCAGCGAAAGCTGTGAGAACGAGTGGTTATGTTTGCGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTGAGTTGGCGCGTTTTGGTGAACAAAAGGTTCTGATTGTTGAACGCTTTGACCGGCGTTGGGCGCGG
GATAACAGCTGGTTGATTCGTTTGCCGCAGGAGGATTTCTGCCAGGCGTTAGGCATTGCCCCTGCGCTGAAATATGAGGC
TGATGGTGGGCCCGGTATTGCGGCTGCGATGCAATTGTTAATGGGTTCTCAACAGCCATTACTCGATCGAGACACCTTCT
TTAAAAGCCAAATCGTCTTCTGGATGCTGGCGGCCATTGATGGGCATGCCAAAAACTTTAGCCTGTTCATTGAGCAGGAA
ACGGCCTATCGAATGACTCCACTTTATGATGTGCTCTCGGGTTACCCATTCATGCATGCCCGTGGCATTGCACCACAGAA
AACCAAAATGGCCATGGCGGCGATTGGGAAGGGCCGCCATTACCGTTGGAGCCAGATCTTGCCTCGGCACTTTATCTCTA
CCGCGAGAGCGGTGGGGTATTCCGAAGAGAAAACGCTACAGGTGATGGCTGATCTGAAAGCGCAAACGGAGCAGGCGATC
GCTAATGTGGAAGCAATGCTGCCGGACGAGTTTCCCCGTTCTGTGAGTGATGCGATTTTTTCTGGGGTTCGGCGGCAGGC
CGAGAGGTTGCTGGGGTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT151701 NZ_CP049848:25506-25571 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Antitoxin