Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4930988..4931529 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag G9W35_RS24030 Protein ID WP_000615976.1
Coordinates 4931251..4931529 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag G9W35_RS24025 Protein ID WP_000729704.1
Coordinates 4930988..4931248 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS24000 (4926771) 4926771..4927556 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
G9W35_RS24005 (4927528) 4927528..4929240 + 1713 Protein_4698 flagellar biosynthesis protein FlhA -
G9W35_RS24010 (4929345) 4929345..4929623 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
G9W35_RS24015 (4929616) 4929616..4929972 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
G9W35_RS24020 (4930029) 4930029..4930802 - 774 WP_000543899.1 C40 family peptidase -
G9W35_RS24025 (4930988) 4930988..4931248 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
G9W35_RS24030 (4931251) 4931251..4931529 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
G9W35_RS24035 (4931685) 4931685..4932425 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
G9W35_RS24040 (4932396) 4932396..4933163 - 768 WP_000333380.1 class II glutamine amidotransferase -
G9W35_RS24045 (4933369) 4933369..4933947 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / rhs/PAAR / vgrG/tssI 4876570..4946620 70050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T151698 WP_000615976.1 NZ_CP049845:4931251-4931529 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T151698 NZ_CP065673:c947306-946989 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACGGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAACGATATCATCGA
GCAATTAAATCGCCGAGTTATGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCAGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT151698 WP_000729704.1 NZ_CP049845:4930988-4931248 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT151698 NZ_CP065673:c947545-947309 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTACTACGCTGAATACTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGGAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGAAGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References