Detailed information of TA system TA151670

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 19138..19402
• Replicon: plasmid pEcoUTI1d
• Accession: NZ_CP049844
• Organism: Escherichia coli strain UPEC-455U/190220

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Y6M3
• Locus tag: G9W36_RS24920
• Protein ID: WP_001331364.1
• Coordinates: 19138..19290 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	19345..19402 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W36_RS24895 (14415)	14415..16583	+	2169	WP_000698357.1	DotA/TraY family protein	-
G9W36_RS24900 (16657)	16657..17307	+	651	WP_001178506.1	plasmid IncI1-type surface exclusion protein ExcA	-
G9W36_RS24905 (17379)	17379..17588	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
G9W36_RS24910 (17980)	17980..18156	+	177	WP_001054898.1	hypothetical protein	-
G9W36_RS25590 (18221)	18221..18453	-	233	Protein_18	hypothetical protein	-
G9W36_RS24915 (18815)	18815..19066	+	252	WP_001291964.1	hypothetical protein	-
G9W36_RS24920 (19138)	19138..19290	-	153	WP_001331364.1	Hok/Gef family protein	Toxin
- (19345)	19345..19402	+	58	NuclAT_0	-	Antitoxin
- (19345)	19345..19402	+	58	NuclAT_0	-	Antitoxin
- (19345)	19345..19402	+	58	NuclAT_0	-	Antitoxin
- (19345)	19345..19402	+	58	NuclAT_0	-	Antitoxin
- (19643)	19643..19698	+	56	NuclAT_1	-	-
- (19643)	19643..19698	+	56	NuclAT_1	-	-
- (19643)	19643..19698	+	56	NuclAT_1	-	-
- (19643)	19643..19698	+	56	NuclAT_1	-	-
G9W36_RS24925 (19892)	19892..20845	+	954	WP_021513958.1	hypothetical protein	-
G9W36_RS24930 (21063)	21063..22271	+	1209	WP_048257178.1	IncI1-type conjugal transfer protein TrbA	-
G9W36_RS24935 (22290)	22290..23360	+	1071	WP_000151583.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..88163	88163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5775.13 Da
• Isoelectric Point: 8.7948

>T151670 WP_001331364.1 NZ_CP049844:c19290-19138 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T151670 NZ_CP065650:3425454-3425804 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT151670 NZ_CP049844:19345-19402 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A5W9M382

Antitoxin