Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4078720..4079447 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag G9W36_RS19775 Protein ID WP_000550189.1
Coordinates 4079133..4079447 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G9W36_RS19770 Protein ID WP_000560266.1
Coordinates 4078720..4079136 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS19760 (4073880) 4073880..4076231 + 2352 WP_000695487.1 alpha-glucosidase -
G9W36_RS19765 (4076657) 4076657..4078675 + 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
G9W36_RS19770 (4078720) 4078720..4079136 - 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
G9W36_RS19775 (4079133) 4079133..4079447 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
G9W36_RS19780 (4079731) 4079731..4080867 - 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
G9W36_RS19785 (4080952) 4080952..4081455 + 504 WP_001333820.1 M48 family metallopeptidase -
G9W36_RS19790 (4081532) 4081532..4082224 + 693 WP_000942548.1 vancomycin high temperature exclusion protein -
G9W36_RS19795 (4082303) 4082303..4083289 + 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T151665 WP_000550189.1 NZ_CP049839:c4079447-4079133 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T151665 NZ_CP065640:c4496976-4496536 [Serratia rubidaea]
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGTGAAGTGCTGGCGGTATTTAA
TCAGCACGCGGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTACACGGCGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCACACTAC
GGCAATATTCGCGCCGATCTTGAACGTAAAGGCACGCCGATTGGGGTTAACGACCTGCATATCGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCGCGAGTTTGCCCGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CACCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT151665 WP_000560266.1 NZ_CP049839:c4079136-4078720 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT151665 NZ_CP065640:c4497209-4496973 [Serratia rubidaea]
ATGACTATCGGTTCCGTTTTTACCAATAATCGCTCGCAGGCGGTACGTTTGCCGGCAGAGGCGCGTTTTCCTGATTCGGT
GTCGAAAGTGACGGTGCGCGTGGTGGGTAAAGAGCGCGTTCTGGCCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACC
AGGAGAGCCTGTCTGGTGATGATTTTCTGAATGAAAGAGCCGCGCAGTATCAGGCTGAGCGGGAAAGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References