Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4014179..4014872 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G9W36_RS19470 Protein ID WP_000415584.1
Coordinates 4014576..4014872 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G9W36_RS19465 Protein ID WP_000650107.1
Coordinates 4014179..4014574 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS19455 (4010043) 4010043..4012301 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
G9W36_RS19460 (4012439) 4012439..4014046 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G9W36_RS19465 (4014179) 4014179..4014574 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G9W36_RS19470 (4014576) 4014576..4014872 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G9W36_RS19475 (4015077) 4015077..4015559 - 483 WP_000183505.1 GyrI-like domain-containing protein -
G9W36_RS19480 (4015612) 4015612..4016004 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G9W36_RS19485 (4016156) 4016156..4016815 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
G9W36_RS19490 (4016812) 4016812..4018161 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
G9W36_RS19495 (4018207) 4018207..4018539 - 333 WP_000917685.1 DUF2645 family protein -
G9W36_RS19500 (4018858) 4018858..4019439 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
G9W36_RS19505 (4019470) 4019470..4019784 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4005716..4014872 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T151664 WP_000415584.1 NZ_CP049839:c4014872-4014576 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T151664 NZ_CP065640:c4348534-4348438 [Serratia rubidaea]
AACAAGCCCTGCAATAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT151664 WP_000650107.1 NZ_CP049839:c4014574-4014179 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT151664 NZ_CP065640:4348438-4348551 [Serratia rubidaea]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTATTGCAGGGCTTGTTCAGCCATGCACTTTAAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References