Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2842447..2842949 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag G9W36_RS14050 Protein ID WP_000767822.1
Coordinates 2842447..2842701 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G9W36_RS14055 Protein ID WP_001259255.1
Coordinates 2842698..2842949 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS14030 (2838940) 2838940..2840298 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
G9W36_RS14035 (2840288) 2840288..2840350 - 63 WP_010723108.1 membrane protein YoeI -
G9W36_RS14040 (2840565) 2840565..2841494 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
G9W36_RS14045 (2841540) 2841540..2842364 - 825 WP_000754737.1 SDR family oxidoreductase -
G9W36_RS14050 (2842447) 2842447..2842701 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G9W36_RS14055 (2842698) 2842698..2842949 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G9W36_RS14060 (2843232) 2843232..2843282 + 51 WP_001364200.1 his operon leader peptide -
G9W36_RS14065 (2843428) 2843428..2844327 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
G9W36_RS14070 (2844333) 2844333..2845637 + 1305 WP_001445483.1 histidinol dehydrogenase -
G9W36_RS14075 (2845634) 2845634..2846704 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
G9W36_RS14080 (2846704) 2846704..2847771 + 1068 WP_219891812.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T151661 WP_000767822.1 NZ_CP049839:c2842701-2842447 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T151661 NZ_CP065640:c2482683-2482396 [Serratia rubidaea]
ATGACCTACAAGGTCAAATTCCGCGAGTCTGCGCTGAAAGAGTGGAACAGGCTGGATAAAGCGCTACAGCAACAGTTTGC
CAAGAAGCTGAAGAAATGCTGTGAAAATCCCCATATCCCCGCGGCGAAACTACGTGGCATGCCGGGGTGTTACAAAATCA
AGCTGCGGGCCTCTGGATTTCGGTTGGTCTATGAAGTGATCGACGATTGTTTGGTGATAGCCGTCGTTGCCGTCGGTAAG
CGGGAGCGAGGCAGCGTTTACCAATTAAGCAGCGAACGTCTGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT151661 WP_001259255.1 NZ_CP049839:c2842949-2842698 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT151661 NZ_CP065640:c2482931-2482680 [Serratia rubidaea]
GTGCCAAATATCATTCTGAGCGATACCAGCGCCAGCATCAGCGAACTGAAGAAAAACCCCATGGGGACGGTCAACGCCGG
CGAAGGGTATCCGGTCGCCATCCTCAACCGTAATCAGCCCGCATTCTATTGCGTACCGGCAGCCCTGTACGAGCAAATGC
TTGACGTGCTGGATGAGCAGGAACTGGTCAGGCTGGTCAATGAGCGTCGCAACGAAGCACTGATTGACGTCGATCTGGAC
CAGTTTACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References