Detailed information of TA system TA151646

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 691905..692163
• Replicon: chromosome
• Accession: NZ_CP049839
• Organism: Escherichia coli strain UPEC-455U/190220

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: G9W36_RS03335
• Protein ID: WP_000809168.1
• Coordinates: 691905..692057 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	692106..692163 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W36_RS03315	687150..687863	-	714	WP_001102391.1	acidic protein MsyB	-
G9W36_RS03320	687889..688293	-	405	WP_000843687.1	DUF2541 family protein	-
G9W36_RS03325	688665..690581	+	1917	WP_000516135.1	molecular chaperone DnaK	-
G9W36_RS03330	690670..691800	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
G9W36_RS03335	691905..692057	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	692106..692163	+	58	-	-	Antitoxin
G9W36_RS03340	692672..693433	+	762	WP_001274832.1	outer membrane protein OmpK	-
G9W36_RS03345	693453..694946	+	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
G9W36_RS03350	695075..696334	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T151646 WP_000809168.1 NZ_CP049839:c692057-691905 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T151646 NZ_CP065627:c921709-921284 [Delftia acidovorans]
ATGATCGTTGTCGATACCAACGTCATTTCGGAACTCTGGAGGCTTGCGCCCGACTCCAGAGTGCTTGCCTGGATGGACGC
CCAGGCCATTGAAACGCTGCATCTGTCTGCCGTCACCGTGGCAGAACTGCGCTACGGCATTGCAGCTATGCCTGAGGGAA
GGCGCCGCACCATCTACCAGGAGCGACTGGAGCATGAGGTTCTGCCGGCCTTCGCCGGCCGTGTCCTGGCCTTTGACCTG
GACGCGGCAAAGGCCTATGCCGATCTGATGGCGAGCGCGAAGACGCAGGGCAGGGCCATCGCCAAGGCCGATGGCTATAT
AGCGGCCACTGCCATGGCGCATGGGCTGGTGGTGGCAACGCGCGACACCAGTCCGTTCGAGGCCGGTGGGCTGCAGACCA
TCAATCCCTGGACGGCAGCGCCCTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT151646 NZ_CP049839:692106-692163 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin