Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2052500..2053016 Replicon chromosome
Accession NZ_CP049819
Organism Arthrobacter woluwensis strain QTS

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G8758_RS09330 Protein ID WP_279590603.1
Coordinates 2052789..2053016 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G8758_RS09325 Protein ID WP_208186440.1
Coordinates 2052500..2052802 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8758_RS16980 (G8758_09295) 2048340..2049575 - 1236 WP_243874608.1 alpha/beta fold hydrolase -
G8758_RS09310 (G8758_09300) 2049640..2050578 - 939 WP_208186435.1 DMT family transporter -
G8758_RS09315 (G8758_09305) 2050651..2051556 + 906 WP_208186437.1 LysR family transcriptional regulator -
G8758_RS09320 (G8758_09310) 2051636..2052466 + 831 WP_208186438.1 oxidoreductase -
G8758_RS09325 (G8758_09315) 2052500..2052802 - 303 WP_208186440.1 HigA family addiction module antitoxin Antitoxin
G8758_RS09330 (G8758_09320) 2052789..2053016 - 228 WP_279590603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8758_RS09335 (G8758_09325) 2053664..2054503 - 840 WP_208186443.1 hypothetical protein -
G8758_RS09340 (G8758_09330) 2054579..2055442 - 864 WP_208186444.1 AraC family transcriptional regulator -
G8758_RS09345 (G8758_09335) 2055677..2056015 - 339 WP_208186445.1 DUF86 domain-containing protein -
G8758_RS09350 (G8758_09340) 2056012..2056455 - 444 WP_243874609.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-75)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-71)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8452.66 Da        Isoelectric Point: 8.0787

>T151625 WP_279590603.1 NZ_CP049819:c2053016-2052789 [Arthrobacter woluwensis]
VPSIDSRIHRVALRKLRQLAAAESLADLRVPPGNRLEALAVGRAGQHSIRINDQWRICFQWTDAGPVEVEIVDYH

Download         Length: 228 bp

>T151625 NZ_CP065624:c880589-880191 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11193.91 Da        Isoelectric Point: 6.4632

>AT151625 WP_208186440.1 NZ_CP049819:c2052802-2052500 [Arthrobacter woluwensis]
MTITERLAPVHPGEVLLADFIEGFGITQNKLAVSINVPPRRINEIVHGKRAITADTALRLARYFGTTPQFWLNLQIQYEL
DRAEDRLAGQIAEITPLQVA

Download         Length: 303 bp

>AT151625 NZ_CP065624:c880816-880589 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References