Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4216..4714 Replicon plasmid pA1254_4
Accession NZ_CP049810
Organism Acinetobacter pittii strain A1254

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G8E09_RS19800 Protein ID WP_167564521.1
Coordinates 4216..4449 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G8E09_RS19805 Protein ID WP_130114462.1
Coordinates 4442..4714 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8E09_RS19765 1..438 + 438 Protein_0 hypothetical protein -
G8E09_RS19770 511..753 - 243 WP_001015364.1 hypothetical protein -
G8E09_RS19775 902..1126 + 225 WP_002072934.1 hypothetical protein -
G8E09_RS19780 1200..2201 - 1002 WP_167564517.1 hypothetical protein -
G8E09_RS19785 2417..2638 + 222 WP_167564518.1 hypothetical protein -
G8E09_RS19790 2732..3244 + 513 WP_167564519.1 type II toxin-antitoxin system YafO family toxin -
G8E09_RS19795 3402..4133 - 732 WP_167564520.1 hypothetical protein -
G8E09_RS19800 4216..4449 + 234 WP_167564521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8E09_RS19805 4442..4714 + 273 WP_130114462.1 helix-turn-helix domain-containing protein Antitoxin
G8E09_RS19820 5981..6547 - 567 WP_167564522.1 plasmid replication DNA-binding protein -
G8E09_RS19825 6611..7540 - 930 WP_000200914.1 replication initiation protein RepM -
G8E09_RS19830 8040..9200 - 1161 WP_000179382.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11269 11269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(12-73)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8699.01 Da        Isoelectric Point: 9.8640

>T151624 WP_167564521.1 NZ_CP049810:4216-4449 [Acinetobacter pittii]
MVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAYPKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 234 bp

>T151624 NZ_CP065624:c19237-19134 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10036.49 Da        Isoelectric Point: 8.6797

>AT151624 WP_130114462.1 NZ_CP049810:4442-4714 [Acinetobacter pittii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTALELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT151624 NZ_CP065624:19133-19364 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References