Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 222189..222708 Replicon chromosome
Accession NZ_CP049802
Organism Staphylococcus warneri strain Cap 100.1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A364USX6
Locus tag G9P47_RS01040 Protein ID WP_002466416.1
Coordinates 222436..222708 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2T4PYE3
Locus tag G9P47_RS01035 Protein ID WP_002466398.1
Coordinates 222189..222443 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P47_RS01020 (G9P47_01030) 217706..219028 + 1323 WP_002466404.1 PrsW family glutamic-type intramembrane protease -
G9P47_RS01025 (G9P47_01035) 219179..219616 + 438 WP_002466379.1 hypothetical protein -
G9P47_RS01030 (G9P47_01040) 219743..221944 - 2202 WP_002466389.1 YSIRK-type signal peptide-containing protein -
G9P47_RS01035 (G9P47_01045) 222189..222443 + 255 WP_002466398.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G9P47_RS01040 (G9P47_01050) 222436..222708 + 273 WP_002466416.1 Txe/YoeB family addiction module toxin Toxin
G9P47_RS01045 (G9P47_01055) 223101..224471 + 1371 WP_002450206.1 citrate:proton symporter -
G9P47_RS01050 (G9P47_01060) 224564..225202 - 639 WP_002466369.1 NAD(P)H-dependent oxidoreductase -
G9P47_RS01055 (G9P47_01065) 225489..226920 + 1432 Protein_207 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10852.63 Da        Isoelectric Point: 9.9029

>T151614 WP_002466416.1 NZ_CP049802:222436-222708 [Staphylococcus warneri]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINQLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYHYFK

Download         Length: 273 bp

>T151614 NZ_CP065615:4751915-4752250 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9345.27 Da        Isoelectric Point: 4.0334

>AT151614 WP_002466398.1 NZ_CP049802:222189-222443 [Staphylococcus warneri]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ESYE

Download         Length: 255 bp

>AT151614 NZ_CP065615:4751667-4751915 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364USX6

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PYE3

References