Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4482483..4483300 Replicon chromosome
Accession NZ_CP049795
Organism Delftia sp. WY8

Toxin (Protein)


Gene name yhaV Uniprot ID A0A072THA9
Locus tag G4D77_RS20635 Protein ID WP_043790975.1
Coordinates 4482483..4482974 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A072T676
Locus tag G4D77_RS20640 Protein ID WP_043790977.1
Coordinates 4482971..4483300 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4D77_RS20605 4477610..4478107 + 498 WP_154833463.1 cobalamin biosynthesis protein -
G4D77_RS20610 4478104..4478982 + 879 WP_154833464.1 precorrin-4 C(11)-methyltransferase -
G4D77_RS20615 4478979..4479776 + 798 WP_154833465.1 precorrin-6A synthase (deacetylating) -
G4D77_RS20620 4479840..4480169 + 330 WP_013800515.1 DHCW motif cupin fold protein -
G4D77_RS20625 4480444..4481841 + 1398 WP_017406579.1 chloride channel protein -
G4D77_RS20630 4481956..4482468 + 513 WP_016448386.1 MgtC/SapB family protein -
G4D77_RS20635 4482483..4482974 - 492 WP_043790975.1 type II toxin-antitoxin system YhaV family toxin Toxin
G4D77_RS20640 4482971..4483300 - 330 WP_043790977.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
G4D77_RS20645 4483397..4485640 - 2244 WP_154833466.1 TonB-dependent receptor -
G4D77_RS20650 4485764..4486159 - 396 WP_154833467.1 hypothetical protein -
G4D77_RS20655 4486187..4486849 - 663 WP_154833468.1 pyridoxamine 5'-phosphate oxidase family protein -
G4D77_RS20660 4486920..4487753 + 834 WP_154833469.1 helix-turn-helix transcriptional regulator -
G4D77_RS20665 4487820..4488095 + 276 WP_016448378.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18801.33 Da        Isoelectric Point: 9.9304

>T151610 WP_043790975.1 NZ_CP049795:c4482974-4482483 [Delftia sp. WY8]
MSAVPPAPLRIHGWTVFMHPLFLAQLQALSHEVEGLKTKDPGGYTRKNATKRLAAIRKLAFDVIPQDPTRPDYRQGHTLG
EEHKHWFRARFFQQYRLFFRFHAPSKIIVFAWVNDEDTRRAYEGSDDAYRVFRKMLANGHPPGDWDSLLAQAESPPPDSQ
PHA

Download         Length: 492 bp

>T151610 NZ_CP065615:c4132924-4132817 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12066.48 Da        Isoelectric Point: 4.1858

>AT151610 WP_043790977.1 NZ_CP049795:c4483300-4482971 [Delftia sp. WY8]
MFSTLEAESTLTDRYQTTIPEAVRRALHLSKRDRIHYTILPGGEVVLSRADSTEDADPVLGQFLGFLAQDMAAHPERLQT
MDARLAQQIQALTEGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT151610 NZ_CP065615:4132973-4133038 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A072THA9

Antitoxin

Source ID Structure
AlphaFold DB A0A072T676

References