Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4852944..4853546 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS23220 Protein ID WP_106995744.1
Coordinates 4853235..4853546 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS23215 Protein ID WP_166184926.1
Coordinates 4852944..4853234 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS23200 4850445..4851347 + 903 WP_106995747.1 formate dehydrogenase subunit beta -
G7090_RS23205 4851344..4851979 + 636 WP_106995746.1 formate dehydrogenase cytochrome b556 subunit -
G7090_RS23210 4851976..4852905 + 930 WP_166184923.1 formate dehydrogenase accessory protein FdhE -
G7090_RS23215 4852944..4853234 - 291 WP_166184926.1 helix-turn-helix domain-containing protein Antitoxin
G7090_RS23220 4853235..4853546 - 312 WP_106995744.1 toxin HigB-2 Toxin
G7090_RS23225 4853853..4854095 + 243 WP_106995743.1 type II toxin-antitoxin system ParD family antitoxin -
G7090_RS23230 4854088..4854375 + 288 WP_166184929.1 type II toxin-antitoxin system RelE/ParE family toxin -
G7090_RS23235 4854381..4855322 - 942 WP_166184932.1 fatty acid biosynthesis protein FabY -
G7090_RS23240 4855367..4855804 - 438 WP_106995740.1 D-tyrosyl-tRNA(Tyr) deacylase -
G7090_RS23245 4855801..4856682 - 882 WP_106995739.1 virulence factor BrkB family protein -
G7090_RS23250 4856676..4857275 - 600 WP_106995738.1 glucose-1-phosphatase -
G7090_RS23255 4857394..4858194 - 801 WP_166184935.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12148.07 Da        Isoelectric Point: 8.4610

>T151589 WP_106995744.1 NZ_CP049786:c4853546-4853235 [Leclercia sp. 29361]
MLFIETDIFTEDVKELLDDDEYHKLQVFLATQPDYGDLIQHTGGLRKIRWLAGGKGKRSGVRVIYFHRSRENEIRLLLIY
RKGIKDDLSANEKAVLKMIIERW

Download         Length: 312 bp

>T151589 NZ_CP065613:c3373086-3372799 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10675.21 Da        Isoelectric Point: 10.7588

>AT151589 WP_166184926.1 NZ_CP049786:c4853234-4852944 [Leclercia sp. 29361]
MDKALFERLTQSVAQMNDIAEGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT151589 NZ_CP065613:c3372812-3372510 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References