Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3745170..3745881 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS17855 Protein ID WP_166183527.1
Coordinates 3745170..3745493 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS17860 Protein ID WP_166183529.1
Coordinates 3745537..3745881 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS17830 3741302..3741988 + 687 WP_166183518.1 RluA family pseudouridine synthase -
G7090_RS17835 3742011..3742394 - 384 WP_166183521.1 VOC family protein -
G7090_RS17840 3742479..3743252 - 774 WP_166183523.1 helix-turn-helix transcriptional regulator -
G7090_RS17845 3743311..3744021 + 711 WP_166185430.1 type 1 glutamine amidotransferase -
G7090_RS17850 3744056..3744949 + 894 WP_166183525.1 PhzF family phenazine biosynthesis protein -
G7090_RS17855 3745170..3745493 + 324 WP_166183527.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7090_RS17860 3745537..3745881 + 345 WP_166183529.1 HigA family addiction module antidote protein Antitoxin
G7090_RS17865 3746275..3746712 + 438 WP_166183531.1 hypothetical protein -
G7090_RS17870 3746774..3747337 + 564 WP_106994955.1 hypothetical protein -
G7090_RS17875 3747418..3747591 + 174 WP_166183533.1 hypothetical protein -
G7090_RS17880 3747656..3748174 - 519 WP_166183535.1 hypothetical protein -
G7090_RS17885 3748761..3748946 + 186 WP_032613375.1 general stress protein -
G7090_RS17890 3749039..3749533 + 495 WP_166183537.1 ferritin-like domain-containing protein -
G7090_RS17895 3749565..3750071 + 507 WP_106994952.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12241.13 Da        Isoelectric Point: 10.1298

>T151587 WP_166183527.1 NZ_CP049786:3745170-3745493 [Leclercia sp. 29361]
MTTPLTLRSISDFRDTWLEEFFLYGRPHGKIPAEIASALMRKLDIINAATSYRDLRSPPGNKLEALSSPLLGCYSIRVNR
QYRLIFIWSGGKAKGIYLDPHTYNAHR

Download         Length: 324 bp

>T151587 NZ_CP065613:c2452968-2452861 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13025.94 Da        Isoelectric Point: 6.4834

>AT151587 WP_166183529.1 NZ_CP049786:3745537-3745881 [Leclercia sp. 29361]
MAFTNSTRKPTTPGDILLNEFLEPLHLKIADLAEMLNVHRNSVSALVNNNRKLTTDMAVRLARAFDTTIEFWLNLQLNVD
IWEIQHDERMQAEHQQIITAAEMLAKRKAQSSVA

Download         Length: 345 bp

>AT151587 NZ_CP065613:2453017-2453082 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References