Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3054542..3055201 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS14735 Protein ID WP_166182903.1
Coordinates 3054848..3055201 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS14730 Protein ID WP_106993446.1
Coordinates 3054542..3054844 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS14695 3050132..3051745 + 1614 WP_166182900.1 sensor histidine kinase -
G7090_RS14700 3051742..3052467 + 726 WP_106993444.1 two-component system response regulator DcuR -
G7090_RS14710 3052814..3053611 + 798 WP_106993445.1 DgsA anti-repressor MtfA -
G7090_RS14720 3053846..3054178 - 333 WP_166182901.1 type II toxin-antitoxin system PemK/MazF family toxin -
G7090_RS14725 3054179..3054436 - 258 WP_166182902.1 antitoxin -
G7090_RS14730 3054542..3054844 - 303 WP_106993446.1 helix-turn-helix transcriptional regulator Antitoxin
G7090_RS14735 3054848..3055201 - 354 WP_166182903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7090_RS14740 3055396..3056346 - 951 WP_166182904.1 HTH-type transcriptional regulator Cbl -
G7090_RS14745 3056443..3057360 - 918 WP_106993448.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13548.59 Da        Isoelectric Point: 9.0971

>T151586 WP_166182903.1 NZ_CP049786:c3055201-3054848 [Leclercia sp. 29361]
VWKIETTDTFDRWLSSLDDRERSAMLAALIVLQTKGPLLPRPWADTIKRSRYHNMKELRVQCGGQPLRAFFAFDPFRTGI
ILCAGNKAGNEKRFYEEMIPLADRELTAYLNNKEGKE

Download         Length: 354 bp

>T151586 NZ_CP065613:c2452485-2452378 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10971.71 Da        Isoelectric Point: 5.7600

>AT151586 WP_106993446.1 NZ_CP049786:c3054844-3054542 [Leclercia sp. 29361]
MGRTLEQLLAEEKPEVVEAAKAIAEEMLLNIHLAELREKVNKTQNEMAQALGLKQPTVAGMEKAGRDIKLSTLKRYVEAA
GGKLRVEVDLPDGSHYGFAL

Download         Length: 303 bp

>AT151586 NZ_CP065613:2452543-2452599 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References