151574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2059803..2060530 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS09820 Protein ID WP_166182261.1
Coordinates 2060219..2060530 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS09815 Protein ID WP_079899847.1
Coordinates 2059803..2060222 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS09775 2054859..2055068 + 210 WP_032617775.1 fumarate hydratase FumD -
G7090_RS09780 2055049..2055735 - 687 WP_166182255.1 ABC transporter permease subunit -
G7090_RS09785 2055720..2056496 - 777 WP_166182256.1 amino acid ABC transporter permease -
G7090_RS09790 2056496..2057308 - 813 WP_166182257.1 amino acid ABC transporter ATP-binding protein -
G7090_RS09795 2057310..2058128 - 819 WP_166182258.1 ABC transporter substrate-binding protein -
G7090_RS09800 2058291..2058452 + 162 WP_166182259.1 hypothetical protein -
G7090_RS09805 2058511..2059090 + 580 Protein_1912 phage tail protein -
G7090_RS09810 2059115..2059732 - 618 WP_166182260.1 hypothetical protein -
G7090_RS09815 2059803..2060222 - 420 WP_079899847.1 helix-turn-helix domain-containing protein Antitoxin
G7090_RS09820 2060219..2060530 - 312 WP_166182261.1 type II toxin-antitoxin system HigB family toxin Toxin
G7090_RS09825 2061070..2062398 + 1329 WP_166182262.1 two-component sensor histidine kinase -
G7090_RS09830 2062391..2063014 + 624 WP_166182263.1 response regulator -
G7090_RS09835 2063092..2063574 + 483 WP_166182264.1 heme-binding protein -
G7090_RS09840 2063637..2063777 - 141 WP_032617828.1 hypothetical protein -
G7090_RS09845 2063905..2064717 + 813 WP_166182265.1 MBL fold metallo-hydrolase -
G7090_RS09850 2064761..2065396 + 636 WP_166182266.1 carbonic anhydrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12347.07 Da        Isoelectric Point: 9.7248

>T151574 WP_166182261.1 NZ_CP049786:c2060530-2060219 [Leclercia sp. 29361]
MHVISKEPFEEAAKQYPNDSLAIRALYRVVRETDFSSPAEMRTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

>T151574 NZ_CP065613:c76684-75362 [Escherichia coli]
ATGCCCAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACTTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGGGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTTCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTATGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGGATACACAT
CAGCGATCTCAAACTGGCAATGGGACTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCAGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15395.50 Da        Isoelectric Point: 4.4420

>AT151574 WP_079899847.1 NZ_CP049786:c2060222-2059803 [Leclercia sp. 29361]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEMPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT151574 NZ_CP065613:c76950-76684 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References