Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1003162..1003808 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS04735 Protein ID WP_166181673.1
Coordinates 1003162..1003494 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS04740 Protein ID WP_106992073.1
Coordinates 1003491..1003808 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS04710 999309..1000265 - 957 WP_166181669.1 xanthine dehydrogenase family protein subunit M -
G7090_RS04715 1000262..1000936 - 675 WP_166181670.1 aldehyde dehydrogenase iron-sulfur subunit -
G7090_RS04720 1001162..1002106 - 945 WP_207630097.1 GNAT family N-acetyltransferase -
G7090_RS04725 1002167..1002499 - 333 WP_166181671.1 DUF1294 domain-containing protein -
G7090_RS04730 1002565..1003026 - 462 WP_166181672.1 GNAT family N-acetyltransferase -
G7090_RS04735 1003162..1003494 + 333 WP_166181673.1 toxin Toxin
G7090_RS04740 1003491..1003808 + 318 WP_106992073.1 helix-turn-helix domain-containing protein Antitoxin
G7090_RS04745 1003859..1005643 - 1785 WP_166181674.1 diguanylate cyclase -
G7090_RS04750 1005658..1006767 - 1110 WP_166181675.1 AI-2E family transporter -
G7090_RS04755 1007189..1008586 + 1398 WP_166181676.1 S-methylmethionine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 986024..1003808 17784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-88)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13071.86 Da        Isoelectric Point: 9.5442

>T151572 WP_166181673.1 NZ_CP049786:1003162-1003494 [Leclercia sp. 29361]
MEAIFIELPAFERYRAEYLSDDAYREFQNVLLANPTAGEVIRDSGGLRKVRFVDERRGKGKRGGIRVIYYWWKTETEFYL
FTLYDKDQASDLTKEQRQTLKHALERIKGK

Download         Length: 333 bp

>T151572 NZ_CP065612:109216-109701 [Escherichia coli]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12170.99 Da        Isoelectric Point: 9.7305

>AT151572 WP_106992073.1 NZ_CP049786:1003491-1003808 [Leclercia sp. 29361]
MMSRDIFSELMEGMDALQEHKEGKRTLRTHHVAIRQETDLTPEEIKDIRRDLNLSQALFARYLHTATRTYQNWEQGLAKP
NRQAALLIRIVQKSPQALSLLAAMN

Download         Length: 318 bp

>AT151572 NZ_CP065612:108944-109228 [Escherichia coli]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References