Detailed information of TA system TA151572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1003162..1003808
• Replicon: chromosome
• Accession: NZ_CP049786
• Organism: Leclercia sp. 29361

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: G7090_RS04735
• Protein ID: WP_166181673.1
• Coordinates: 1003162..1003494 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: G7090_RS04740
• Protein ID: WP_106992073.1
• Coordinates: 1003491..1003808 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7090_RS04710	999309..1000265	-	957	WP_166181669.1	xanthine dehydrogenase family protein subunit M	-
G7090_RS04715	1000262..1000936	-	675	WP_166181670.1	aldehyde dehydrogenase iron-sulfur subunit	-
G7090_RS04720	1001162..1002106	-	945	WP_207630097.1	GNAT family N-acetyltransferase	-
G7090_RS04725	1002167..1002499	-	333	WP_166181671.1	DUF1294 domain-containing protein	-
G7090_RS04730	1002565..1003026	-	462	WP_166181672.1	GNAT family N-acetyltransferase	-
G7090_RS04735	1003162..1003494	+	333	WP_166181673.1	toxin	Toxin
G7090_RS04740	1003491..1003808	+	318	WP_106992073.1	helix-turn-helix domain-containing protein	Antitoxin
G7090_RS04745	1003859..1005643	-	1785	WP_166181674.1	diguanylate cyclase	-
G7090_RS04750	1005658..1006767	-	1110	WP_166181675.1	AI-2E family transporter	-
G7090_RS04755	1007189..1008586	+	1398	WP_166181676.1	S-methylmethionine permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	986024..1003808	17784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-88)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 13071.86 Da
• Isoelectric Point: 9.5442

>T151572 WP_166181673.1 NZ_CP049786:1003162-1003494 [Leclercia sp. 29361]
MEAIFIELPAFERYRAEYLSDDAYREFQNVLLANPTAGEVIRDSGGLRKVRFVDERRGKGKRGGIRVIYYWWKTETEFYL
FTLYDKDQASDLTKEQRQTLKHALERIKGK

Nucleotide

• Length: 333 bp

>T151572 NZ_CP065612:109216-109701 [Escherichia coli]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12170.99 Da
• Isoelectric Point: 9.7305

>AT151572 WP_106992073.1 NZ_CP049786:1003491-1003808 [Leclercia sp. 29361]
MMSRDIFSELMEGMDALQEHKEGKRTLRTHHVAIRQETDLTPEEIKDIRRDLNLSQALFARYLHTATRTYQNWEQGLAKP
NRQAALLIRIVQKSPQALSLLAAMN

Nucleotide

• Length: 318 bp

>AT151572 NZ_CP065612:108944-109228 [Escherichia coli]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA