Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 268435..269124 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7090_RS01255 Protein ID WP_166181290.1
Coordinates 268435..268752 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7090_RS01260 Protein ID WP_166181292.1
Coordinates 268828..269124 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS01230 263948..265267 + 1320 WP_166181283.1 MATE family efflux transporter DinF -
G7090_RS01235 265409..265618 + 210 WP_032615972.1 CsbD family protein -
G7090_RS01240 265688..266203 - 516 WP_032615974.1 zinc uptake transcriptional repressor Zur -
G7090_RS01245 266316..266804 + 489 WP_166181286.1 cupin domain-containing protein -
G7090_RS01250 266968..268278 + 1311 WP_166181288.1 conjugal transfer protein TraF -
G7090_RS01255 268435..268752 + 318 WP_166181290.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7090_RS01260 268828..269124 + 297 WP_166181292.1 helix-turn-helix domain-containing protein Antitoxin
G7090_RS01265 269260..270297 + 1038 WP_166181294.1 tRNA dihydrouridine(20/20a) synthase DusA -
G7090_RS01270 270442..270684 + 243 WP_106993932.1 envelope stress response protein PspG -
G7090_RS01275 270868..271851 - 984 WP_166181296.1 quinone oxidoreductase -
G7090_RS01280 271923..273335 + 1413 WP_106993934.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-86)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12057.83 Da        Isoelectric Point: 9.4166

>T151569 WP_166181290.1 NZ_CP049786:268435-268752 [Leclercia sp. 29361]
MFTFIELQGFSKQRQALLPDDEFRAFQEALIEDPEAGDTIAGTGGFRKIRWSRPGMGKRGGVRVIYYNVTRKGRIYLALV
YPKNEQDDLTEEQKKVLKQLSDMLA

Download         Length: 318 bp

>T151569 NZ_CP065611:c4917071-4916964 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11086.77 Da        Isoelectric Point: 6.4711

>AT151569 WP_166181292.1 NZ_CP049786:268828-269124 [Leclercia sp. 29361]
MKDELFADLLASAEEMVRIEKGEQTPEPEHVHTFSPIDVKAIREATGLKQQDFAAAVGVSYDLVRSWETKRRQPTGAPRK
LLLLLQTNPFIINQLKTI

Download         Length: 297 bp

>AT151569 NZ_CP065611:4917118-4917184 [Escherichia coli]
TGTCTGGTTTCAAGATTAGTCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References