Detailed information of TA system TA151554

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2650039..2650313
• Replicon: chromosome
• Accession: NZ_CP049775
• Organism: Enterococcus faecalis strain ES-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: G7X26_RS12870
• Protein ID: WP_002392696.1
• Coordinates: 2650170..2650313 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2650039..2650237 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7X26_RS12850	2645041..2645754	-	714	WP_002354877.1	trehalose operon repressor	-
G7X26_RS12855	2646016..2648760	+	2745	WP_070416068.1	glycoside hydrolase family 65 protein	-
G7X26_RS12860	2648775..2649425	+	651	WP_002354875.1	beta-phosphoglucomutase	-
G7X26_RS12865	2649795..2649947	-	153	WP_002354873.1	putative holin-like toxin	-
-	2650039..2650237	+	199	-	-	Antitoxin
G7X26_RS12870	2650170..2650313	-	144	WP_002392696.1	putative holin-like toxin	Toxin
G7X26_RS12875	2650544..2651515	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
G7X26_RS12880	2651690..2652127	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
G7X26_RS12885	2652260..2652814	-	555	WP_002354869.1	septum formation protein Maf	-
G7X26_RS12890	2652839..2654971	-	2133	WP_070416067.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T151554 WP_002392696.1 NZ_CP049775:c2650313-2650170 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T151554 NZ_CP065611:754550-754840 [Escherichia coli]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT151554 NZ_CP049775:2650039-2650237 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin