Detailed information of TA system TA151547

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2649676..2649947
• Replicon: chromosome
• Accession: NZ_CP049775
• Organism: Enterococcus faecalis strain ES-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A2P6B8G0
• Locus tag: G7X26_RS12865
• Protein ID: WP_002354873.1
• Coordinates: 2649795..2649947 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2649676..2649821 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7X26_RS12850	2645041..2645754	-	714	WP_002354877.1	trehalose operon repressor	-
G7X26_RS12855	2646016..2648760	+	2745	WP_070416068.1	glycoside hydrolase family 65 protein	-
G7X26_RS12860	2648775..2649425	+	651	WP_002354875.1	beta-phosphoglucomutase	-
-	2649676..2649821	+	146	-	-	Antitoxin
G7X26_RS12865	2649795..2649947	-	153	WP_002354873.1	putative holin-like toxin	Toxin
G7X26_RS12870	2650170..2650313	-	144	WP_002392696.1	putative holin-like toxin	-
G7X26_RS12875	2650544..2651515	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
G7X26_RS12880	2651690..2652127	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
G7X26_RS12885	2652260..2652814	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5651.89 Da
• Isoelectric Point: 10.9857

>T151547 WP_002354873.1 NZ_CP049775:c2649947-2649795 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 153 bp

>T151547 NZ_CP065607:c4735945-4735796 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 146 bp

>AT151547 NZ_CP049775:2649676-2649821 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: A0A2P6B8G0

Antitoxin