Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 769551..770326 Replicon chromosome
Accession NZ_CP049719
Organism Klebsiella pneumoniae strain 06KM907

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag G7Z28_RS03895 Protein ID WP_004150910.1
Coordinates 769841..770326 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag G7Z28_RS03890 Protein ID WP_004150912.1
Coordinates 769551..769844 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z28_RS03870 764759..765361 - 603 WP_002916735.1 short chain dehydrogenase -
G7Z28_RS03875 765459..766370 + 912 WP_004188550.1 LysR family transcriptional regulator -
G7Z28_RS03880 766371..767519 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
G7Z28_RS03885 767530..768906 - 1377 WP_004217775.1 cystathionine beta-synthase -
G7Z28_RS03890 769551..769844 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
G7Z28_RS03895 769841..770326 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
G7Z28_RS03900 771030..771623 + 594 WP_004188553.1 hypothetical protein -
G7Z28_RS03905 771720..771936 + 217 Protein_768 transposase -
G7Z28_RS03910 772542..773414 + 873 WP_004188557.1 ParA family protein -
G7Z28_RS03915 773414..773797 + 384 WP_004150906.1 hypothetical protein -
G7Z28_RS03920 773790..775157 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 771720..771872 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T151457 WP_004150910.1 NZ_CP049719:769841-770326 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T151457 NZ_CP065522:473513-473776 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGAACTTAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACACCTTGGCACCCAACCAAGGCTTTGAAAAATTGGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATTACGAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT151457 WP_004150912.1 NZ_CP049719:769551-769844 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT151457 NZ_CP065522:473262-473516 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGATAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References