Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 437427..437937 Replicon chromosome
Accession NZ_CP049684
Organism Polynucleobacter paneuropaeus strain AP-Creno-5A-D2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag C2742_RS02320 Protein ID WP_112203283.1
Coordinates 437674..437937 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C2742_RS02315 Protein ID WP_112203281.1
Coordinates 437427..437684 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2742_RS02280 (C2742_02280) 432537..432980 - 444 WP_112208912.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
C2742_RS02285 (C2742_02285) 433011..433397 - 387 Protein_444 ribosome silencing factor -
C2742_RS02290 (C2742_02290) 433433..434122 - 690 WP_215278937.1 nicotinate (nicotinamide) nucleotide adenylyltransferase -
C2742_RS02295 (C2742_02295) 434123..435034 - 912 WP_251365270.1 oxygen-dependent coproporphyrinogen oxidase -
C2742_RS02300 (C2742_02300) 435071..436348 - 1278 WP_112237703.1 phosphoribosylamine--glycine ligase -
C2742_RS02305 (C2742_02305) 436361..437080 - 720 WP_112203279.1 YebC/PmpR family DNA-binding transcriptional regulator -
C2742_RS02315 (C2742_02315) 437427..437684 + 258 WP_112203281.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2742_RS02320 (C2742_02320) 437674..437937 + 264 WP_112203283.1 Txe/YoeB family addiction module toxin Toxin
C2742_RS02325 (C2742_02325) 437942..438883 - 942 WP_112203285.1 CysB family HTH-type transcriptional regulator -
C2742_RS02330 (C2742_02330) 438947..440101 - 1155 WP_215274503.1 LPS export ABC transporter permease LptG -
C2742_RS02335 (C2742_02335) 440098..441213 - 1116 WP_215278938.1 LPS export ABC transporter permease LptF -
C2742_RS02340 (C2742_02340) 441324..442901 + 1578 WP_215278939.1 leucyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10209.77 Da        Isoelectric Point: 9.4082

>T151418 WP_112203283.1 NZ_CP049684:437674-437937 [Polynucleobacter paneuropaeus]
MRSDLVWTSAAWSDYLYWQGQDKKTLKRINLLIKDAIRNPAEGIGKPEALKENLSGLWSRRIDDVNRLVYVIEKDQLVII
ACRYHYS

Download         Length: 264 bp

>T151418 NZ_CP065464:2577141-2578463 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9638.03 Da        Isoelectric Point: 8.5493

>AT151418 WP_112203281.1 NZ_CP049684:437427-437684 [Polynucleobacter paneuropaeus]
MRVINFSDARNQFKQVIDQVVADSDVTIISRRDAEDAVVMSLDTYNSMMETVHLLKSPANVKHLEKSLAQYRKGQTKAKA
LVDEK

Download         Length: 258 bp

>AT151418 NZ_CP065464:2576875-2577141 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References