Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 320242..320833 Replicon chromosome
Accession NZ_CP049682
Organism Polynucleobacter paneuropaeus strain AP-RePozz9-10-D2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2750_RS01740 Protein ID WP_112203122.1
Coordinates 320242..320520 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2750_RS01745 Protein ID WP_215272412.1
Coordinates 320528..320833 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2750_RS01715 (C2750_01715) 315469..316497 - 1029 WP_215286139.1 ionic transporter y4hA -
C2750_RS01720 (C2750_01720) 316597..316959 + 363 WP_215286140.1 CbiX/SirB N-terminal domain-containing protein -
C2750_RS01725 (C2750_01725) 316882..317730 - 849 WP_215272148.1 uroporphyrinogen-III C-methyltransferase -
C2750_RS01730 (C2750_01730) 317759..318349 - 591 WP_215272149.1 DUF934 domain-containing protein -
C2750_RS01735 (C2750_01735) 318346..320070 - 1725 WP_215286141.1 nitrite/sulfite reductase -
C2750_RS01740 (C2750_01740) 320242..320520 + 279 WP_112203122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2750_RS01745 (C2750_01745) 320528..320833 + 306 WP_215272412.1 HigA family addiction module antitoxin Antitoxin
C2750_RS01750 (C2750_01750) 320884..321132 + 249 WP_112203124.1 prevent-host-death family protein -
C2750_RS01755 (C2750_01755) 321216..321575 - 360 WP_215278913.1 hypothetical protein -
C2750_RS01760 (C2750_01760) 321589..321810 - 222 WP_112208850.1 hypothetical protein -
C2750_RS01765 (C2750_01765) 321982..322575 + 594 WP_215278914.1 DUF308 domain-containing protein -
C2750_RS01770 (C2750_01770) 322618..322788 + 171 WP_158525527.1 hypothetical protein -
C2750_RS01775 (C2750_01775) 322804..324960 + 2157 WP_215278915.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.35 Da        Isoelectric Point: 10.1614

>T151409 WP_112203122.1 NZ_CP049682:320242-320520 [Polynucleobacter paneuropaeus]
MIHSFLCGLTKDLFDSKPSKKFGNIERAARRKLLQLHAATAISDLRTPPGNMLELLIGNRRGQYSIRINHQWRICFVWRE
DGAHNVEIVDYH

Download         Length: 279 bp

>T151409 NZ_CP065460:c5381815-5380898 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11701.62 Da        Isoelectric Point: 5.7251

>AT151409 WP_215272412.1 NZ_CP049682:320528-320833 [Polynucleobacter paneuropaeus]
MTTKLLDEIHPGEILLEDFMKPMGITSRQLAADIDVSPSRISEIIHGTRPITADTALRLGLFFSMEPRFWLNLQSEYDMR
MAKRNLQEEIEPRIRVFRIAA

Download         Length: 306 bp

>AT151409 NZ_CP065460:c5382579-5381821 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References