Detailed information of TA system TA151406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 437430..437940
• Replicon: chromosome
• Accession: NZ_CP049681
• Organism: Polynucleobacter paneuropaeus strain AP-RePozz9-5-D10

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C2752_RS02320
• Protein ID: WP_112203283.1
• Coordinates: 437677..437940 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C2752_RS02315
• Protein ID: WP_112203281.1
• Coordinates: 437430..437687 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2752_RS02280 (C2752_02280)	432540..432983	-	444	WP_112208912.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
C2752_RS02285 (C2752_02285)	433014..433400	-	387	Protein_444	ribosome silencing factor	-
C2752_RS02290 (C2752_02290)	433436..434125	-	690	WP_215278937.1	nicotinate (nicotinamide) nucleotide adenylyltransferase	-
C2752_RS02295 (C2752_02295)	434126..435037	-	912	WP_251365270.1	oxygen-dependent coproporphyrinogen oxidase	-
C2752_RS02300 (C2752_02300)	435074..436351	-	1278	WP_112237703.1	phosphoribosylamine--glycine ligase	-
C2752_RS02305 (C2752_02305)	436364..437083	-	720	WP_112203279.1	YebC/PmpR family DNA-binding transcriptional regulator	-
C2752_RS02315 (C2752_02315)	437430..437687	+	258	WP_112203281.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C2752_RS02320 (C2752_02320)	437677..437940	+	264	WP_112203283.1	Txe/YoeB family addiction module toxin	Toxin
C2752_RS02325 (C2752_02325)	437945..438886	-	942	WP_112203285.1	CysB family HTH-type transcriptional regulator	-
C2752_RS02330 (C2752_02330)	438950..440104	-	1155	WP_215274503.1	LPS export ABC transporter permease LptG	-
C2752_RS02335 (C2752_02335)	440101..441216	-	1116	WP_215278938.1	LPS export ABC transporter permease LptF	-
C2752_RS02340 (C2752_02340)	441327..442904	+	1578	WP_215278939.1	leucyl aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10209.77 Da
• Isoelectric Point: 9.4082

>T151406 WP_112203283.1 NZ_CP049681:437677-437940 [Polynucleobacter paneuropaeus]
MRSDLVWTSAAWSDYLYWQGQDKKTLKRINLLIKDAIRNPAEGIGKPEALKENLSGLWSRRIDDVNRLVYVIEKDQLVII
ACRYHYS

Nucleotide

• Length: 264 bp

>T151406 NZ_CP065460:4508031-4508249 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9638.03 Da
• Isoelectric Point: 8.5493

>AT151406 WP_112203281.1 NZ_CP049681:437430-437687 [Polynucleobacter paneuropaeus]
MRVINFSDARNQFKQVIDQVVADSDVTIISRRDAEDAVVMSLDTYNSMMETVHLLKSPANVKHLEKSLAQYRKGQTKAKA
LVDEK

Nucleotide

• Length: 258 bp

>AT151406 NZ_CP065460:4507630-4508004 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG