Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 333352..333943 Replicon chromosome
Accession NZ_CP049681
Organism Polynucleobacter paneuropaeus strain AP-RePozz9-5-D10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2752_RS01805 Protein ID WP_112203122.1
Coordinates 333352..333630 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2752_RS01810 Protein ID WP_215272412.1
Coordinates 333638..333943 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2752_RS01780 (C2752_01780) 328695..329714 - 1020 WP_215278909.1 ionic transporter y4hA -
C2752_RS01785 (C2752_01785) 329785..330147 + 363 WP_215278910.1 CbiX/SirB N-terminal domain-containing protein -
C2752_RS01790 (C2752_01790) 330070..330882 - 813 WP_215279087.1 uroporphyrinogen-III C-methyltransferase -
C2752_RS01795 (C2752_01795) 330894..331484 - 591 WP_215278911.1 DUF934 domain-containing protein -
C2752_RS01800 (C2752_01800) 331481..333181 - 1701 WP_215278912.1 nitrite/sulfite reductase -
C2752_RS01805 (C2752_01805) 333352..333630 + 279 WP_112203122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2752_RS01810 (C2752_01810) 333638..333943 + 306 WP_215272412.1 HigA family addiction module antitoxin Antitoxin
C2752_RS01815 (C2752_01815) 333994..334242 + 249 WP_112203124.1 prevent-host-death family protein -
C2752_RS01820 (C2752_01820) 334326..334685 - 360 WP_215278913.1 hypothetical protein -
C2752_RS01825 (C2752_01825) 334699..334920 - 222 WP_112208850.1 hypothetical protein -
C2752_RS01830 (C2752_01830) 335119..335685 + 567 WP_251366896.1 DUF308 domain-containing protein -
C2752_RS01835 (C2752_01835) 335728..335898 + 171 WP_158525527.1 hypothetical protein -
C2752_RS01840 (C2752_01840) 335914..338070 + 2157 WP_215278915.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.35 Da        Isoelectric Point: 10.1614

>T151405 WP_112203122.1 NZ_CP049681:333352-333630 [Polynucleobacter paneuropaeus]
MIHSFLCGLTKDLFDSKPSKKFGNIERAARRKLLQLHAATAISDLRTPPGNMLELLIGNRRGQYSIRINHQWRICFVWRE
DGAHNVEIVDYH

Download         Length: 279 bp

>T151405 NZ_CP065460:c3045540-3044218 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11701.62 Da        Isoelectric Point: 5.7251

>AT151405 WP_215272412.1 NZ_CP049681:333638-333943 [Polynucleobacter paneuropaeus]
MTTKLLDEIHPGEILLEDFMKPMGITSRQLAADIDVSPSRISEIIHGTRPITADTALRLGLFFSMEPRFWLNLQSEYDMR
MAKRNLQEEIEPRIRVFRIAA

Download         Length: 306 bp

>AT151405 NZ_CP065460:c3045806-3045540 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References