Detailed information of TA system TA151402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 424266..424776
• Replicon: chromosome
• Accession: NZ_CP049680
• Organism: Polynucleobacter paneuropaeus strain AP-RePozz9-5-G2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C2753_RS02255
• Protein ID: WP_112203283.1
• Coordinates: 424513..424776 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C2753_RS02250
• Protein ID: WP_112203281.1
• Coordinates: 424266..424523 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2753_RS02215 (C2753_02215)	419376..419819	-	444	WP_112294852.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
C2753_RS02220 (C2753_02220)	419850..420236	-	387	Protein_431	ribosome silencing factor	-
C2753_RS02225 (C2753_02225)	420272..420961	-	690	WP_215283875.1	nicotinate (nicotinamide) nucleotide adenylyltransferase	-
C2753_RS02230 (C2753_02230)	420962..421873	-	912	WP_244973711.1	oxygen-dependent coproporphyrinogen oxidase	-
C2753_RS02235 (C2753_02235)	421910..423187	-	1278	WP_112208914.1	phosphoribosylamine--glycine ligase	-
C2753_RS02240 (C2753_02240)	423200..423919	-	720	WP_112203279.1	YebC/PmpR family DNA-binding transcriptional regulator	-
C2753_RS02250 (C2753_02250)	424266..424523	+	258	WP_112203281.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C2753_RS02255 (C2753_02255)	424513..424776	+	264	WP_112203283.1	Txe/YoeB family addiction module toxin	Toxin
C2753_RS02260 (C2753_02260)	424781..425722	-	942	WP_215286155.1	CysB family HTH-type transcriptional regulator	-
C2753_RS02265 (C2753_02265)	425786..426940	-	1155	WP_215274503.1	LPS export ABC transporter permease LptG	-
C2753_RS02270 (C2753_02270)	426937..428052	-	1116	WP_112208916.1	LPS export ABC transporter permease LptF	-
C2753_RS02275 (C2753_02275)	428163..429740	+	1578	WP_112313771.1	leucyl aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10209.77 Da
• Isoelectric Point: 9.4082

>T151402 WP_112203283.1 NZ_CP049680:424513-424776 [Polynucleobacter paneuropaeus]
MRSDLVWTSAAWSDYLYWQGQDKKTLKRINLLIKDAIRNPAEGIGKPEALKENLSGLWSRRIDDVNRLVYVIEKDQLVII
ACRYHYS

Nucleotide

• Length: 264 bp

>T151402 NZ_CP065460:987870-988355 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9638.03 Da
• Isoelectric Point: 8.5493

>AT151402 WP_112203281.1 NZ_CP049680:424266-424523 [Polynucleobacter paneuropaeus]
MRVINFSDARNQFKQVIDQVVADSDVTIISRRDAEDAVVMSLDTYNSMMETVHLLKSPANVKHLEKSLAQYRKGQTKAKA
LVDEK

Nucleotide

• Length: 258 bp

>AT151402 NZ_CP065460:987580-987873 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA