Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 326589..327180 Replicon chromosome
Accession NZ_CP049679
Organism Polynucleobacter paneuropaeus strain AP-Creno-20-G10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G7Z35_RS01770 Protein ID WP_112203122.1
Coordinates 326589..326867 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G7Z35_RS01775 Protein ID WP_215272412.1
Coordinates 326875..327180 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z35_RS01745 (G7Z35_01750) 321822..322850 - 1029 WP_215279387.1 ionic transporter y4hA -
G7Z35_RS01750 (G7Z35_01755) 322943..323305 + 363 WP_215279388.1 CbiX/SirB N-terminal domain-containing protein -
G7Z35_RS01755 (G7Z35_01760) 323228..324097 - 870 WP_215279389.1 uroporphyrinogen-III C-methyltransferase -
G7Z35_RS01760 (G7Z35_01765) 324124..324708 - 585 WP_215279390.1 DUF934 domain-containing protein -
G7Z35_RS01765 (G7Z35_01770) 324705..326417 - 1713 WP_215279391.1 nitrite/sulfite reductase -
G7Z35_RS01770 (G7Z35_01775) 326589..326867 + 279 WP_112203122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Z35_RS01775 (G7Z35_01780) 326875..327180 + 306 WP_215272412.1 HigA family addiction module antitoxin Antitoxin
G7Z35_RS01780 (G7Z35_01785) 327231..327479 + 249 WP_112203124.1 prevent-host-death family protein -
G7Z35_RS01785 (G7Z35_01790) 327563..327922 - 360 WP_215278264.1 hypothetical protein -
G7Z35_RS01790 (G7Z35_01795) 327931..328152 - 222 WP_112313704.1 hypothetical protein -
G7Z35_RS01795 (G7Z35_01800) 328335..328928 + 594 WP_112238541.1 DUF308 domain-containing protein -
G7Z35_RS01800 (G7Z35_01805) 328971..329141 + 171 WP_158525168.1 hypothetical protein -
G7Z35_RS01805 (G7Z35_01810) 329233..330300 + 1068 WP_215279392.1 acyltransferase -
G7Z35_RS01810 (G7Z35_01815) 330305..330832 - 528 WP_112208855.1 ribosome biogenesis factor YjgA -
G7Z35_RS01815 (G7Z35_01820) 330875..331762 - 888 WP_215274482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.35 Da        Isoelectric Point: 10.1614

>T151397 WP_112203122.1 NZ_CP049679:326589-326867 [Polynucleobacter paneuropaeus]
MIHSFLCGLTKDLFDSKPSKKFGNIERAARRKLLQLHAATAISDLRTPPGNMLELLIGNRRGQYSIRINHQWRICFVWRE
DGAHNVEIVDYH

Download         Length: 279 bp

>T151397 NZ_CP065459:c61010-60528 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11701.62 Da        Isoelectric Point: 5.7251

>AT151397 WP_215272412.1 NZ_CP049679:326875-327180 [Polynucleobacter paneuropaeus]
MTTKLLDEIHPGEILLEDFMKPMGITSRQLAADIDVSPSRISEIIHGTRPITADTALRLGLFFSMEPRFWLNLQSEYDMR
MAKRNLQEEIEPRIRVFRIAA

Download         Length: 306 bp

>AT151397 NZ_CP065459:c61264-60998 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References