Detailed information of TA system TA151386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3874203..3874849
• Replicon: chromosome
• Accession: NZ_CP049608
• Organism: Atlantibacter hermannii strain 78-1320

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FV156_RS18350
• Protein ID: WP_165432041.1
• Coordinates: 3874203..3874556 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FV156_RS18355
• Protein ID: WP_165432042.1
• Coordinates: 3874553..3874849 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV156_RS18340	3869600..3872722	-	3123	WP_165432039.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-
FV156_RS18345	3872722..3873975	-	1254	WP_165432040.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
FV156_RS18350	3874203..3874556	+	354	WP_165432041.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FV156_RS18355	3874553..3874849	+	297	WP_165432042.1	helix-turn-helix transcriptional regulator	Antitoxin
FV156_RS18360	3874872..3876224	-	1353	WP_165432353.1	molecular chaperone	-
FV156_RS18365	3876356..3877210	+	855	WP_165432043.1	DNA-3-methyladenine glycosylase 2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-80)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13594.78 Da
• Isoelectric Point: 10.0566

>T151386 WP_165432041.1 NZ_CP049608:3874203-3874556 [Atlantibacter hermannii]
MTWTVVLTPEFEQWFDKQEAGLQDRINMMITLLEISGPNLGRPHVDILVGSRYPNMKELRIQYAGEPWRVGFAFNHRQQA
VLLYGGQKTGKKRFYTLLIAQVDAIFARDLARKKENL

Nucleotide

• Length: 354 bp

>T151386 NZ_CP065457:346816-347157 [Klebsiella pneumoniae]
ATGAAAACCTTACCTGCAACAATTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACGGTCTGGCAGATGCTGCTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTACCCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCAGGCATCACACTGGTTGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTGGGCGCAGTGGATATTTTGCGGGCGCGACAGGCAACCGGCCTGTTACGGCAAAG
ACATCTTCCTTCGATACGCTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11030.80 Da
• Isoelectric Point: 8.5172

>AT151386 WP_165432042.1 NZ_CP049608:3874553-3874849 [Atlantibacter hermannii]
MKTFQEKLAEYSPERRAKIERMAEAFAAENGLPPLREMRAMSQQELAERLGVTQPAVAAMERRGEDIKVSTLKRYAEALG
GELKITIELPEGRKVISL

Nucleotide

• Length: 297 bp

>AT151386 NZ_CP065457:346466-346792 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCTAATTTTGGCGCAAGGTTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGAAAATTTGGTGACGTCGAATGTCTGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA