Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1048832..1049361 Replicon chromosome
Accession NZ_CP049366
Organism Companilactobacillus pabuli strain NFFJ11

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H4LEM5
Locus tag G6534_RS05070 Protein ID WP_059073490.1
Coordinates 1048832..1049095 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0H4LTF4
Locus tag G6534_RS05075 Protein ID WP_059073360.1
Coordinates 1049098..1049361 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6534_RS05040 1044892..1045104 - 213 WP_182083213.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
G6534_RS05045 1045350..1046231 - 882 WP_059073365.1 LysR family transcriptional regulator -
G6534_RS05050 1046339..1047172 + 834 WP_182083214.1 aldo/keto reductase -
G6534_RS05055 1047174..1047698 + 525 WP_182083215.1 sugar O-acetyltransferase -
G6534_RS05060 1047726..1048076 - 351 WP_059073362.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6534_RS05065 1048069..1048257 - 189 WP_152999934.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
G6534_RS05070 1048832..1049095 - 264 WP_059073490.1 Txe/YoeB family addiction module toxin Toxin
G6534_RS05075 1049098..1049361 - 264 WP_059073360.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6534_RS05080 1049444..1049884 - 441 Protein_969 GNAT family N-acetyltransferase -
G6534_RS05085 1050030..1051292 + 1263 WP_152999932.1 replication-associated recombination protein A -
G6534_RS05090 1051327..1052334 - 1008 WP_059073359.1 alpha/beta hydrolase -
G6534_RS05095 1052359..1053090 - 732 WP_059073358.1 SDR family oxidoreductase -
G6534_RS05100 1053090..1053596 - 507 WP_182083217.1 sugar O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10511.00 Da        Isoelectric Point: 9.9343

>T151323 WP_059073490.1 NZ_CP049366:c1049095-1048832 [Companilactobacillus pabuli]
MSYSIKFKNSSKNDLKKIKNSPFRKKFDEIIKGLSVNPYDPSDNFEKLFPPEDKLYSRRLNIQHRIVYSIDEEKKIVHIY
SAWNHYE

Download         Length: 264 bp

>T151323 NZ_CP065438:1019687-1019971 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9882.01 Da        Isoelectric Point: 4.5895

>AT151323 WP_059073360.1 NZ_CP049366:c1049361-1049098 [Companilactobacillus pabuli]
MQRMTNPTQARKDFYKIIKSVNENSTPIEINGRTEDDSAVIMSAKDYRSLQETLYLMNDGTLNKIHKAIADDSGETDITN
GVDWDKI

Download         Length: 264 bp

>AT151323 NZ_CP065438:1019455-1019697 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H4LEM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4LTF4

References