Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 87947..88626 Replicon plasmid unnamed2
Accession NZ_CP049359
Organism Deinococcus wulumuqiensis R12

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag G6R31_RS15620 Protein ID WP_017871100.1
Coordinates 88264..88626 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag G6R31_RS15615 Protein ID WP_029732691.1
Coordinates 87947..88267 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6R31_RS15585 83984..84223 + 240 WP_152423703.1 hypothetical protein -
G6R31_RS15590 84330..84968 - 639 WP_081608294.1 HNH endonuclease -
G6R31_RS15595 85062..85316 - 255 WP_017871094.1 hypothetical protein -
G6R31_RS15600 85306..85914 - 609 WP_017871095.1 ParA family protein -
G6R31_RS15605 86779..87489 + 711 WP_081608295.1 IS6 family transposase -
G6R31_RS15610 87609..87938 + 330 WP_152423704.1 hypothetical protein -
G6R31_RS15615 87947..88267 - 321 WP_029732691.1 XRE family transcriptional regulator Antitoxin
G6R31_RS15620 88264..88626 - 363 WP_017871100.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6R31_RS15625 88844..89830 - 987 WP_081608296.1 tyrosine-type recombinase/integrase -
G6R31_RS15630 90056..90832 - 777 WP_017871102.1 transposase -
G6R31_RS15635 90900..91805 - 906 WP_017871103.1 IS3 family transposase -
G6R31_RS15640 91802..92071 - 270 WP_017871104.1 transposase -
G6R31_RS15645 92211..92828 + 618 WP_081608298.1 peptidoglycan DD-metalloendopeptidase family protein -
G6R31_RS15650 92887..93363 - 477 WP_161617998.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..222570 222570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(36-95)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13550.41 Da        Isoelectric Point: 4.2687

>T151319 WP_017871100.1 NZ_CP049359:c88626-88264 [Deinococcus wulumuqiensis R12]
MVWEIILVGEVDEWFAGLDHATSQLVTAALDLLEDRGPMLGRPLVDTLTGSQLANLKELRPGSVGQTEIRILFVFDPKRQ
AILLTAGDKAGQWTQWYTEHITLAESRYDLWLAGHYEEEL

Download         Length: 363 bp

>T151319 NZ_CP065438:c105830-105483 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11835.44 Da        Isoelectric Point: 8.6577

>AT151319 WP_029732691.1 NZ_CP049359:c88267-87947 [Deinococcus wulumuqiensis R12]
MKARNWKAVRQEAEQAGRIDESQVAALRGEMLAQVRAYKLAEVRAASGLSQQELAEQLQVSQSRISRIEHGDLDRTELAT
LRKFARAIGGELELTLKLGDERFTLG

Download         Length: 321 bp

>AT151319 NZ_CP065438:c105483-105184 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References