Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1800795..1801297 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G7B60_RS08615 Protein ID WP_000767829.1
Coordinates 1801043..1801297 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G7B60_RS08610 Protein ID WP_001259255.1
Coordinates 1800795..1801046 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS08585 1795973..1797040 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G7B60_RS08590 1797040..1798110 - 1071 WP_001468894.1 histidinol-phosphate transaminase -
G7B60_RS08595 1798107..1799411 - 1305 WP_032214175.1 histidinol dehydrogenase -
G7B60_RS08600 1799417..1800316 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
G7B60_RS08605 1800462..1800512 - 51 WP_001364200.1 his operon leader peptide -
G7B60_RS08610 1800795..1801046 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G7B60_RS08615 1801043..1801297 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G7B60_RS08620 1801380..1802204 + 825 WP_000754749.1 SDR family oxidoreductase -
G7B60_RS08625 1802250..1803179 + 930 WP_000803351.1 LysR family transcriptional regulator -
G7B60_RS08630 1803394..1803456 + 63 WP_010723108.1 membrane protein YoeI -
G7B60_RS08635 1803446..1804804 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G7B60_RS08640 1804983..1806041 + 1059 WP_053276361.1 transport protein YeeE -
G7B60_RS08645 1806055..1806282 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T151288 WP_000767829.1 NZ_CP049353:1801043-1801297 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T151288 NZ_CP065430:717726-717908 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT151288 WP_001259255.1 NZ_CP049353:1800795-1801046 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT151288 NZ_CP065430:717946-718395 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGATACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References