151288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1800795..1801297 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G7B60_RS08615 Protein ID WP_000767829.1
Coordinates 1801043..1801297 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G7B60_RS08610 Protein ID WP_001259255.1
Coordinates 1800795..1801046 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS08585 1795973..1797040 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G7B60_RS08590 1797040..1798110 - 1071 WP_001468894.1 histidinol-phosphate transaminase -
G7B60_RS08595 1798107..1799411 - 1305 WP_032214175.1 histidinol dehydrogenase -
G7B60_RS08600 1799417..1800316 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
G7B60_RS08605 1800462..1800512 - 51 WP_001364200.1 his operon leader peptide -
G7B60_RS08610 1800795..1801046 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G7B60_RS08615 1801043..1801297 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G7B60_RS08620 1801380..1802204 + 825 WP_000754749.1 SDR family oxidoreductase -
G7B60_RS08625 1802250..1803179 + 930 WP_000803351.1 LysR family transcriptional regulator -
G7B60_RS08630 1803394..1803456 + 63 WP_010723108.1 membrane protein YoeI -
G7B60_RS08635 1803446..1804804 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G7B60_RS08640 1804983..1806041 + 1059 WP_053276361.1 transport protein YeeE -
G7B60_RS08645 1806055..1806282 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T151288 WP_000767829.1 NZ_CP049353:1801043-1801297 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T151288 NZ_CP065430:717726-717908 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT151288 WP_001259255.1 NZ_CP049353:1800795-1801046 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT151288 NZ_CP065430:717946-718395 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGATACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References