Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2159668..2160170 Replicon chromosome
Accession NZ_CP049348
Organism Escherichia coli strain 3R

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G6Q95_RS10250 Protein ID WP_000767829.1
Coordinates 2159668..2159922 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S1Y4D6
Locus tag G6Q95_RS10255 Protein ID WP_001259254.1
Coordinates 2159919..2160170 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Q95_RS10220 2154683..2154910 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
G6Q95_RS10225 2154924..2155982 - 1059 WP_024193414.1 transport protein YeeE -
G6Q95_RS10230 2156161..2157519 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G6Q95_RS10235 2157509..2157571 - 63 WP_010723108.1 membrane protein YoeI -
G6Q95_RS10240 2157786..2158715 - 930 WP_000803351.1 LysR family transcriptional regulator -
G6Q95_RS10245 2158761..2159585 - 825 WP_000754737.1 SDR family oxidoreductase -
G6Q95_RS10250 2159668..2159922 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G6Q95_RS10255 2159919..2160170 - 252 WP_001259254.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G6Q95_RS10260 2160453..2160503 + 51 WP_001364200.1 his operon leader peptide -
G6Q95_RS10265 2160649..2161548 + 900 WP_072645750.1 ATP phosphoribosyltransferase -
G6Q95_RS10270 2161554..2162858 + 1305 WP_001345878.1 histidinol dehydrogenase -
G6Q95_RS10275 2162855..2163925 + 1071 WP_072645751.1 histidinol-phosphate transaminase -
G6Q95_RS10280 2163925..2164992 + 1068 WP_000080109.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T151245 WP_000767829.1 NZ_CP049348:c2159922-2159668 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T151245 NZ_CP065404:639367-640260 [Paraburkholderia caribensis]
ATGTCCGCAGCCTTGCCCGTCACTGTCGATCGAACCGTCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACGGCGGAT
CGCGATTGCACTGCAATGCGCGATCGGCTATCGCGAAGCGGGTGCTGGGCATGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGGATCGGCTCGGGCGCGGCTTCGTGGGTGCAACAACTCGAAGCGTTGGGCACGACGCGCCGCGTGTTCGCTTGGGAC
GCGCCGGGCTATGGCGAATCGACGCCCGTTGCATCGGCTTCGCCCAAAGCGGATGAATATGCCGGCGCGCTCGACGCATG
GCTCGATGCGCTCGCCGTAGAACGTTGCGTACTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCTCGTTCGCGGCAT
CGCGTGCGCAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCACGGCATCCGAAGACGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGATGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCCGTACGCCGATGAAGCATCACGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCGAGGGTCGACGGCCCTATCGCTGTCGCGGTCGGGGCG
GAGGACTCGATCACCCCGCCGTCGTCATGTGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9292.57 Da        Isoelectric Point: 4.5822

>AT151245 WP_001259254.1 NZ_CP049348:c2160170-2159919 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE

Download         Length: 252 bp

>AT151245 NZ_CP065404:640257-641117 [Paraburkholderia caribensis]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGGGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTCTCGCCGCGCGAACCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTTACCGATCTCGGCTTGCCGTT
GATCGAAGCTTTGCGCGATGCAACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGCTACCCGCGCATGCGACTACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTCGACGAACTATACGAGCGCGTGAAGGACGACGCGGTGCGCGGTTTCGCGATCAGCGAATCGT
CCTTCGAAAACGGTATCTCCGTCATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACCACCACC
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAATTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1Y4D6

References