Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3668565..3669106 Replicon chromosome
Accession NZ_CP049343
Organism Escherichia coli strain UMB200201_11

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag FM734_RS17515 Protein ID WP_000615976.1
Coordinates 3668828..3669106 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag FM734_RS17510 Protein ID WP_000729704.1
Coordinates 3668565..3668825 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FM734_RS17485 3664348..3665133 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
FM734_RS17490 3665105..3666817 + 1713 Protein_3420 flagellar biosynthesis protein FlhA -
FM734_RS17495 3666922..3667200 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
FM734_RS17500 3667193..3667549 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
FM734_RS17505 3667606..3668379 - 774 WP_000543897.1 C40 family peptidase -
FM734_RS17510 3668565..3668825 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
FM734_RS17515 3668828..3669106 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
FM734_RS17520 3669262..3670002 + 741 WP_001225679.1 murein L,D-transpeptidase -
FM734_RS17525 3669973..3670740 - 768 WP_000333380.1 class II glutamine amidotransferase -
FM734_RS17530 3670946..3671524 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T151228 WP_000615976.1 NZ_CP049343:3668828-3669106 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T151228 NZ_CP065398:c177862-177503 [Bifidobacterium longum]
ATGTGGCAGATAGAGATGGAACCCATCAAGGACTGGCTTGACGGACTTGACAAACAGACCGCCTACCAAGTCTACGCGGC
CCTTGACCTCCTTCGGGAACGCGGACCGAACCTCAAACGCCCCCTGGTGGGGAAAATCGAGGGCTCCATCATCGGCTCCA
TGAAGGAACTGAGACCCGGTTCGACAGGTCGAAGCGAAGTCCGAATCCTGTTCGTCTTCGACCCGGAACGCAAAGCGGTC
CTATTGGTCGGCGGAGACAAACAGAACAAATGGAACAAATGGTATAAGACAGCCATCCGCGAAGCCGAACGACGGTACAT
CCGGTGGCTGGAAGAACAACATGGGAAGGACACGAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT151228 WP_000729704.1 NZ_CP049343:3668565-3668825 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT151228 NZ_CP065398:c177506-177198 [Bifidobacterium longum]
ATGAGCTACACGTTGGAGGACTTCAAGGCCGATCACGACCTTGACCAGAAGACCATCGACGAGCGCAAGGAACAGCTTCT
TGAGGAGATGCGCCTGTATGAGCTGAAAGAAGCGCGCAAACAGCAGGACGTGACCCAGAAGCAGCTCGCCGAACGCATGG
GCGTCAGCCAGAAGCGGGTCAGCAGCCTCGAATCCGGCGACGTCGACAAGACCGAAATCCGTACGCTGCGCCGCTATCTC
GACGCCATCGGCGGCAGGCTTCAGGTCAACGCGATCATGCCGGACGGGCGCACCCTGCAACTGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References