Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1496025..1496618 Replicon chromosome
Accession NZ_CP049316
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag SBC2_RS06455 Protein ID WP_206366019.1
Coordinates 1496340..1496618 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SBC2_RS06450 Protein ID WP_165088512.1
Coordinates 1496025..1496327 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS06440 1492826..1494532 - 1707 WP_165088506.1 single-stranded-DNA-specific exonuclease RecJ -
SBC2_RS06445 1494610..1495719 - 1110 WP_165088509.1 regulator -
SBC2_RS06450 1496025..1496327 - 303 WP_165088512.1 HigA family addiction module antidote protein Antitoxin
SBC2_RS06455 1496340..1496618 - 279 WP_206366019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SBC2_RS06460 1497090..1498343 + 1254 WP_165088520.1 lipoprotein-releasing ABC transporter permease subunit -
SBC2_RS06465 1498336..1499043 + 708 WP_165088523.1 lipoprotein-releasing ABC transporter ATP-binding protein LolD -
SBC2_RS06470 1499077..1499865 + 789 WP_165088528.1 TatD family hydrolase -
SBC2_RS41770 1499909..1500628 - 720 WP_206366020.1 hypothetical protein -
SBC2_RS06480 1500891..1501076 + 186 Protein_1279 TatD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10474.08 Da        Isoelectric Point: 10.1581

>T151198 WP_206366019.1 NZ_CP049316:c1496618-1496340 [Caballeronia sp. SBC2]
MIQTFRCKDTQALYEGGTPKRFRAIADVAIRRLSALDAAVEIRDLKSPPGNRLESLAGDRRGQLSIRINGQWRVCFKWTT
KGLVDVEIIDYH

Download         Length: 279 bp

>T151198 NZ_CP065369:c821300-821004 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAACTGAGTAAATTAGCTCAGGCTCATTTACGGAAAATTAAAAGCTATACAGTGAACAATTT
CTCCGAGATGCAATGGCGAAGCTATAAAGATACGTTACTAACTGGTTTTCAAATGCTTGCTGATAATCCAGCTGTTGGTC
GCAGTTGCGATGAAATATACCCAAGCGGATTCTATTTCCCTGTAGGCAAGCATACCGCTTACTTTACAAAAGAAGATGGT
TTCATATTAGTTGTAGCTATACTCGGTCAATCACTGCTTCCTCAGAACCATTTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11572.37 Da        Isoelectric Point: 8.4844

>AT151198 WP_165088512.1 NZ_CP049316:c1496327-1496025 [Caballeronia sp. SBC2]
MSKNGMRPVHPGEVLREDYLVPLEMSVNALALALNVPATRMHEIVKERRGITADTAYRLARYFDSTPEFWLNLQAMYDLK
TLPTRTEIDRKVEPRELSRA

Download         Length: 303 bp

>AT151198 NZ_CP065369:c821549-821307 [Vibrio parahaemolyticus]
ATGCATACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGCTACTCCTAAGCGCCCAACGTGAGCCTGTGAAGAT
TAGCAAGAACAGTAAAGATGCCGTAGTTGTAATGTCTATCAAGGACTATGAAGAACTAGAAGCAATGAAAGCCGATTACC
TTAGACATTGCTTCGAGTCCGCAAAACAAGACTTAGCACAAGGTGATGTGGTTGATGGTGAAGACTTTTTAAATGCCTTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References