Detailed information of TA system TA151172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1117452..1117993
• Replicon: chromosome
• Accession: NZ_CP049289
• Organism: Bradyrhizobium sp. 6(2017) strain 1S3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: G6P99_RS05310
• Protein ID: WP_165123551.1
• Coordinates: 1117727..1117993 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: G6P99_RS05305
• Protein ID: WP_165123549.1
• Coordinates: 1117452..1117730 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6P99_RS05275	1112499..1112732	+	234	WP_029081904.1	hypothetical protein	-
G6P99_RS05280	1112830..1113072	+	243	WP_029081903.1	hypothetical protein	-
G6P99_RS05285	1114196..1114396	+	201	WP_165123541.1	hypothetical protein	-
G6P99_RS05290	1114393..1114875	+	483	WP_165123543.1	hypothetical protein	-
G6P99_RS05295	1114875..1116053	+	1179	WP_165123545.1	hypothetical protein	-
G6P99_RS05300	1116643..1117230	+	588	WP_165123547.1	recombinase family protein	-
G6P99_RS05305	1117452..1117730	+	279	WP_165123549.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G6P99_RS05310	1117727..1117993	+	267	WP_165123551.1	Txe/YoeB family addiction module toxin	Toxin
G6P99_RS05315	1118130..1118570	+	441	WP_165123553.1	hypothetical protein	-
G6P99_RS05320	1118567..1120135	+	1569	WP_205751509.1	hypothetical protein	-
G6P99_RS05325	1120138..1120494	+	357	WP_165123555.1	hypothetical protein	-
G6P99_RS05330	1120501..1121304	+	804	WP_165123557.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1104808..1126162	21354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10413.79 Da
• Isoelectric Point: 8.0427

>T151172 WP_165123551.1 NZ_CP049289:1117727-1117993 [Bradyrhizobium sp. 6(2017)]
MKTAWTEDAWQDYVQWQKEDEKVLEAINDLIKDIKRDPFRGLGKPEPLKHALAGWWSRRITGEHRLVYRVSGSGDAKQLD
IAQCRYHY

Nucleotide

• Length: 267 bp

>T151172 NZ_CP065354:c821375-821187 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTTTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10093.54 Da
• Isoelectric Point: 4.8355

>AT151172 WP_165123549.1 NZ_CP049289:1117452-1117730 [Bradyrhizobium sp. 6(2017)]
MAIVSYTELRNNLASFMDGVCDGRAPLFVTRQNARTVVLIAEDEYEGLMETVHLLKSPANAARLLRSIKEADEGKLTERE
LIEPTKAASTAA

Nucleotide

• Length: 279 bp

>AT151172 NZ_CP065354:c821664-821404 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA