151136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1702560..1703062 Replicon chromosome
Accession NZ_CP049281
Organism Shigella boydii strain 600657

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G5S55_RS08775 Protein ID WP_000767829.1
Coordinates 1702808..1703062 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G5S55_RS08770 Protein ID WP_001259255.1
Coordinates 1702560..1702811 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S55_RS08745 1697739..1698806 - 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G5S55_RS08750 1698806..1699876 - 1071 WP_000108980.1 histidinol-phosphate transaminase -
G5S55_RS08755 1699873..1701177 - 1305 WP_039060143.1 histidinol dehydrogenase -
G5S55_RS08760 1701183..1702082 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
G5S55_RS08765 1702227..1702277 - 51 WP_001364200.1 his operon leader peptide -
G5S55_RS08770 1702560..1702811 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G5S55_RS08775 1702808..1703062 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G5S55_RS08780 1703145..1703969 + 825 WP_000754747.1 SDR family oxidoreductase -
G5S55_RS08785 1704015..1704944 + 930 WP_039059232.1 LysR family transcriptional regulator -
G5S55_RS08790 1705159..1705221 + 63 WP_010723108.1 membrane protein YoeI -
G5S55_RS08795 1705211..1706569 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G5S55_RS08800 1706779..1707708 + 930 WP_024258582.1 YeeE/YedE family protein -
G5S55_RS08805 1707722..1707949 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T151136 WP_000767829.1 NZ_CP049281:1702808-1703062 [Shigella boydii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T151136 NZ_CP065343:c3393183-3393081 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT151136 WP_001259255.1 NZ_CP049281:1702560-1702811 [Shigella boydii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT151136 NZ_CP065343:3393074-3393219 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References