Detailed information of TA system TA151109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 1182591..1183132
• Replicon: chromosome
• Accession: NZ_CP049278
• Organism: Shigella boydii strain 600690

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: G5S56_RS05620
• Protein ID: WP_000615975.1
• Coordinates: 1182591..1182869 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: S1EWQ0
• Locus tag: G5S56_RS05625
• Protein ID: WP_000729704.1
• Coordinates: 1182872..1183132 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S56_RS05590 (1177857)	1177857..1178627	-	771	WP_001118012.1	2-oxoglutaramate amidase	-
G5S56_RS05595 (1178808)	1178808..1179254	+	447	WP_284522444.1	Ivy family C-type lysozyme inhibitor	-
G5S56_RS05600 (1179297)	1179297..1180052	-	756	Protein_1090	DUF1974 domain-containing protein	-
G5S56_RS05605 (1180173)	1180173..1180751	+	579	WP_000284050.1	D-sedoheptulose 7-phosphate isomerase	-
G5S56_RS05610 (1180957)	1180957..1181724	+	768	WP_078167336.1	class II glutamine amidotransferase	-
G5S56_RS05615 (1181695)	1181695..1182435	-	741	WP_001225684.1	peptidoglycan meso-diaminopimelic acid protein amidase	-
G5S56_RS05620 (1182591)	1182591..1182869	-	279	WP_000615975.1	type II toxin-antitoxin system mRNA interferase toxin YafQ	Toxin
G5S56_RS05625 (1182872)	1182872..1183132	-	261	WP_000729704.1	type II toxin-antitoxin system antitoxin DinJ	Antitoxin
G5S56_RS05630 (1183216)	1183216..1184372	+	1157	WP_086020980.1	IS3-like element IS600 family transposase	-
G5S56_RS05635 (1184418)	1184418..1184753	-	336	Protein_1097	helix-turn-helix domain-containing protein	-
G5S56_RS05640 (1184926)	1184926..1185354	+	429	WP_284522445.1	hypothetical protein	-
G5S56_RS05645 (1185443)	1185443..1186671	+	1229	WP_171764983.1	IS3-like element IS2 family transposase	-
G5S56_RS05650 (1186646)	1186646..1187509	+	864	WP_284522446.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1176701..1177819	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10853.66 Da
• Isoelectric Point: 10.0703

>T151109 WP_000615975.1 NZ_CP049278:c1182869-1182591 [Shigella boydii]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINHTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Nucleotide

• Length: 279 bp

>T151109 NZ_CP065258:c2413311-2412943 [Streptomyces clavuligerus]
ATGCACTACCTCACCCTGCCCGAGCTGCTGAACCTCGCGGAGCGGCTGCGGGCGGCCGAGGTGCGCGACTACGGTCTGCT
GGACTCCGCCCTCGCGCGCCCCCAGGCGAGCGTCTTCGGCCAGGACGCCTACCCGGATGTCTGGCAGAAGGCCGCCGCCC
TGATGGAGTCCCTGGCCCGCAACCACGGACTGGTCGACGGCAACAAGCGGATCGCCTGGTATGCCACCTGGGTCTTTCTC
CATGTGAACGGCCATCCGCTGGACCCGGAATTCGACGTGGACGAGGCGGAACGGTTTGTTCTGGACGTCTGCCAGGGGGC
ACTCGACGTCCCCAAGATCGCGTCGGGGCTGCTGCGCTTCGCCCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9391.77 Da
• Isoelectric Point: 5.0758

>AT151109 WP_000729704.1 NZ_CP049278:c1183132-1182872 [Shigella boydii]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT151109 NZ_CP065258:c2413508-2413311 [Streptomyces clavuligerus]
ATGGCTGGTCTCAATGTGCGATTCACCGAGGAAGAGCTCACCGCCCTGCGGGAGCGGGCCGAAGCGGAGGGCCGCAGTAT
GCAGTCCTTCGCGCACGACGCGGTGATCAGAGCGATCAACGAACGCGCGCGGCTGTTCAACGAGGCCGCCGAGCATGTGC
TGAGGGCGAGCGAGGAGCTGAACCGGAGGCTCGCCTGA

Structures

Antitoxin

• PDB: 4ML0
• AlphaFold DB: A0A0E0Y6Z6