Detailed information of TA system TA151099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 562244..562697
• Replicon: chromosome
• Accession: NZ_CP049272
• Organism: Campylobacter concisus strain P27CDO-S2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CVT17_RS02775
• Protein ID: WP_107769653.1
• Coordinates: 562503..562697 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CVT17_RS02770
• Protein ID: WP_087576737.1
• Coordinates: 562244..562516 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT17_RS02750	557840..559168	-	1329	WP_107769656.1	aminotransferase class V-fold PLP-dependent enzyme	-
CVT17_RS02755	559352..559540	-	189	WP_107769655.1	sodium-dependent tyrosine transporter	-
CVT17_RS02760	559531..560322	-	792	WP_107769654.1	LysR family transcriptional regulator	-
CVT17_RS02765	560315..561097	-	783	WP_103600472.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
CVT17_RS02770	562244..562516	-	273	WP_087576737.1	helix-turn-helix domain-containing protein	Antitoxin
CVT17_RS02775	562503..562697	-	195	WP_107769653.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT17_RS02780	562675..563199	+	525	Protein_536	type I restriction endonuclease subunit R	-
CVT17_RS02785	563189..563847	+	659	Protein_537	M48 family metallopeptidase	-
CVT17_RS02795	564161..564679	-	519	WP_072594769.1	inorganic diphosphatase	-
CVT17_RS02800	564750..565085	-	336	WP_107769652.1	NirD/YgiW/YdeI family stress tolerance protein	-
CVT17_RS02805	565159..565623	-	465	WP_107769651.1	hypothetical protein	-
CVT17_RS02810	565710..566279	-	570	WP_107770042.1	adenylate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (3-56)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-86)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7456.82 Da
• Isoelectric Point: 10.2638

>T151099 WP_107769653.1 NZ_CP049272:c562697-562503 [Campylobacter concisus]
MIVNDGLFEIRIKSDEGIAKSIYCYEIGKRIIILLTFVKKTQKTPKSILNLAEQRLREFKDGNR

Nucleotide

• Length: 195 bp

>T151099 NZ_CP065233:3231927-3232634 [Alteromonas sp. B31-7]
GTGGAAAATCAGGAACAAGTCGCCACACTAGGCTATGTGGACACACTCGAAGAACAGGCGGTGCTTGAAGAGTTACTTGA
AACCTCAAAACCCGACTATCCTGATACCTACCCAAACACCCTGCACTACCTGCTCAAAACACCTTTTCGTTATCCTCCCT
TACACTGGGGATCTCGATTTGGCCGTATCCATGAACCTAGCCTGTTCTACGGCGGAAAATCACTTGAAGTAACCCTGGCA
GAATCCGCCTTCTACCGCTTTGTGTTTCTCCGCTCAATGGAAGGAACGGCACCTGCGGCAAAATTGAACACCGAGCATAC
GCTGTTCACAGTGGGTTATAAGACCGATAAAGGTATCCAGCTTCAACAGCCACCCTTTAGTGCATTCACGGCAGCATTGC
GCCACCGCACTGAGTACTCCCTGACTCAAGCATTAGGCACCAACATGAGAGAAGCTGGAGTAGAAGCCTTTGAATATCTA
TCGGCCCGTTCAGCTCGTGATGAGCTGTGCGCAGCCCTCTTTACCCCCATCGCCTTCACTGACCAGGCGCCGCAATCCAG
AGAAAACTGGTTTTGTGAACTAACCCAGGAACAGGTAACCTTTAAAGCAATGGGCTCCCAACAGGTCTTCAGCTTTTGTC
TGGAGGAGTTCTCTGTTAACAGGCTGTTTCCTATGCCAGCCCCATCCGCACCACGGAACCCGGTATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10140.62 Da
• Isoelectric Point: 7.9455

>AT151099 WP_087576737.1 NZ_CP049272:c562516-562244 [Campylobacter concisus]
MGTVNFREVLKEELKNPEFKAQYDALEDEYKAIEALIDARSEAGLTQSEVAKRMGITQSAVARIESGAYNIKYKTFFNYI
KACGKRVAIV

Nucleotide

• Length: 273 bp

>AT151099 NZ_CP065233:3231487-3231858 [Alteromonas sp. B31-7]
ATGACTGCACAACTAAAGCAACGACCAGACCCAGCTGTTGTCCTGTCAAAAGCACTACTTAATGCATCCAAACAGCTGAC
ACTCAAGCAAGATGAGCTGGGCAAGGTGATTGGTGTGCATAGAACCGCGATAACACGCTTAAAGCAAAACCTGGACCTGA
GTCCCGACAGTAAACAAGGTGAACTGGCCCTGCTGTTGATCAGAGCCGCCCGGGCACTATTTGCACTCACCGGGGGTGAC
CAGGCCTGGATCAAACATTTCATGCGCTCACAGAACAAGCTTACTGGCGGTGTTCCTGCTATACAGGTACAAACTGTTCA
GGGACTTATGCGTGTGGTGACCTGCCTGGATGCGATACGAGGCAAGGTGTAA