Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2336982..2337580 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name higB Uniprot ID A0A1B9TH83
Locus tag G6M88_RS11070 Protein ID WP_065699641.1
Coordinates 2336982..2337305 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B9TH82
Locus tag G6M88_RS11075 Protein ID WP_065699640.1
Coordinates 2337302..2337580 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS11050 (G6M88_11070) 2332727..2333317 - 591 WP_065699643.1 GNAT family protein -
G6M88_RS11055 (G6M88_11075) 2333365..2334660 - 1296 WP_045231395.1 pitrilysin family protein -
G6M88_RS11060 (G6M88_11080) 2334677..2336077 - 1401 WP_065699642.1 threonine synthase -
G6M88_RS11065 (G6M88_11085) 2336308..2336862 + 555 WP_178119086.1 PilZ domain-containing protein -
G6M88_RS11070 (G6M88_11090) 2336982..2337305 + 324 WP_065699641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6M88_RS11075 (G6M88_11095) 2337302..2337580 + 279 WP_065699640.1 helix-turn-helix transcriptional regulator Antitoxin
G6M88_RS11080 (G6M88_11100) 2337617..2338306 - 690 WP_065699639.1 HAD family hydrolase -
G6M88_RS11085 (G6M88_11105) 2338468..2339148 + 681 WP_065699638.1 GntR family transcriptional regulator -
G6M88_RS11090 (G6M88_11110) 2339329..2339907 + 579 WP_065699637.1 biotin transporter BioY -
G6M88_RS11095 (G6M88_11115) 2339904..2340350 + 447 WP_065699636.1 DUF1284 domain-containing protein -
G6M88_RS11100 (G6M88_11120) 2340340..2341422 - 1083 WP_065699635.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12021.05 Da        Isoelectric Point: 10.4646

>T151050 WP_065699641.1 NZ_CP049206:2336982-2337305 [Agrobacterium rubi]
MRWSVETHEATDSEIEALPAGLQARLVRLMEAVENIGLEQLREPHVKHLEGKLWELRAKASEGIARGIYVTMTGRRVIVL
HVFVKKSQKTPAGALAIARQRMSEVKP

Download         Length: 324 bp

>T151050 NZ_CP065194:c521854-521666 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9955.30 Da        Isoelectric Point: 9.7311

>AT151050 WP_065699640.1 NZ_CP049206:2337302-2337580 [Agrobacterium rubi]
MTKIADLKNKLMSNPEFRTEYEKADAEFQLIEALVGARTRANLSQAEVARRVGTTQSAIARLEGGGVSPSVATLRRYAEA
TGAKLEINLTST

Download         Length: 279 bp

>AT151050 NZ_CP065194:c522142-521882 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9TH83

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9TH82

References