Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2336982..2337580 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name higB Uniprot ID A0A1B9TH83
Locus tag G6M88_RS11070 Protein ID WP_065699641.1
Coordinates 2336982..2337305 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B9TH82
Locus tag G6M88_RS11075 Protein ID WP_065699640.1
Coordinates 2337302..2337580 (+) Length 93 a.a.

Genomic Context

G6M88_RS11065G6M88_RS11070G6M88_RS11075G6M88_RS11085G6M88_RS11090G6M88_RS11095G6M88_RS11050G6M88_RS11055G6M88_RS11060G6M88_RS11080G6M88_RS11100
Location: 2336308..2336862 (555 bp)
Type: Others
Protein ID: WP_178119086.1
Location: 2336982..2337305 (324 bp)
Type: Toxin
Protein ID: WP_065699641.1
Location: 2337302..2337580 (279 bp)
Type: Antitoxin
Protein ID: WP_065699640.1
Location: 2338468..2339148 (681 bp)
Type: Others
Protein ID: WP_065699638.1
Location: 2339329..2339907 (579 bp)
Type: Others
Protein ID: WP_065699637.1
Location: 2339904..2340350 (447 bp)
Type: Others
Protein ID: WP_065699636.1
Location: 2332727..2333317 (591 bp)
Type: Others
Protein ID: WP_065699643.1
Location: 2333365..2334660 (1296 bp)
Type: Others
Protein ID: WP_045231395.1
Location: 2334677..2336077 (1401 bp)
Type: Others
Protein ID: WP_065699642.1
Location: 2337617..2338306 (690 bp)
Type: Others
Protein ID: WP_065699639.1
Location: 2340340..2341422 (1083 bp)
Type: Others
Protein ID: WP_065699635.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6M88_RS11050 (G6M88_11070)2332727..2333317-591WP_065699643.1GNAT family protein-
G6M88_RS11055 (G6M88_11075)2333365..2334660-1296WP_045231395.1pitrilysin family protein-
G6M88_RS11060 (G6M88_11080)2334677..2336077-1401WP_065699642.1threonine synthase-
G6M88_RS11065 (G6M88_11085)2336308..2336862+555WP_178119086.1PilZ domain-containing protein-
G6M88_RS11070 (G6M88_11090)2336982..2337305+324WP_065699641.1type II toxin-antitoxin system RelE/ParE family toxinToxin
G6M88_RS11075 (G6M88_11095)2337302..2337580+279WP_065699640.1helix-turn-helix transcriptional regulatorAntitoxin
G6M88_RS11080 (G6M88_11100)2337617..2338306-690WP_065699639.1HAD family hydrolase-
G6M88_RS11085 (G6M88_11105)2338468..2339148+681WP_065699638.1GntR family transcriptional regulator-
G6M88_RS11090 (G6M88_11110)2339329..2339907+579WP_065699637.1biotin transporter BioY-
G6M88_RS11095 (G6M88_11115)2339904..2340350+447WP_065699636.1DUF1284 domain-containing protein-
G6M88_RS11100 (G6M88_11120)2340340..2341422-1083WP_065699635.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12021.05 Da        Isoelectric Point: 10.4646

>T151050 WP_065699641.1 NZ_CP049206:2336982-2337305 [Agrobacterium rubi]
MRWSVETHEATDSEIEALPAGLQARLVRLMEAVENIGLEQLREPHVKHLEGKLWELRAKASEGIARGIYVTMTGRRVIVL
HVFVKKSQKTPAGALAIARQRMSEVKP

Download         Length: 324 bp

>T151050 NZ_CP065194:c521854-521666 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9955.30 Da        Isoelectric Point: 9.7311

>AT151050 WP_065699640.1 NZ_CP049206:2337302-2337580 [Agrobacterium rubi]
MTKIADLKNKLMSNPEFRTEYEKADAEFQLIEALVGARTRANLSQAEVARRVGTTQSAIARLEGGGVSPSVATLRRYAEA
TGAKLEINLTST

Download         Length: 279 bp

>AT151050 NZ_CP065194:c522142-521882 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B9TH83

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B9TH82

References